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<jats:title>ABSTRACT</jats:title> <jats:p>We perform a cross-correlation analysis of microwave data from the <jats:italic>Wilkinson Microwave Anisotropy Probe</jats:italic> and photometric quasars from the Sloan Digital Sky Survey, testing for the Sunyaev–Zeldovich (SZ) effect from quasars. A statistically significant (2.5σ) temperature decrement exists in the 41 GHz microwave band. A two-component fit to the cross-correlation spectrum incorporating both dust emission and SZ yields a best-fit <jats:italic>y</jats:italic> parameter of (7.0 ± 3.4) × 10<jats:sup>−7</jats:sup>. A similar cross-correlation analysis with the luminous red galaxy sample from Sloan gives a best-fit <jats:italic>y</jats:italic> parameter of (5.3 ±  2.5) × 10<jats:sup>−7</jats:sup>. We discuss the possible physical origin of these signals, which is likely a combination of SZ effects from quasars and galaxy clusters. Both the <jats:italic>Planck</jats:italic> Surveyor satellite and the current ground-based arcminute-resolution microwave experiments will detect this signal with a higher statistical significance.</jats:p>