Catálogo de publicaciones - revistas

<jats:p>Tissue growth is controlled by the temporal variation in signaling by a morphogen along its concentration gradient.</jats:p>

<jats:p>Light with different frequencies (colors) can be combined to synthesize optical waveforms such as square and sawtooth waves, as well as short pulses.</jats:p>

<jats:p>X-ray crystallography provides some surprising insights into the dynein class of molecular motors.</jats:p>

<jats:p>Mutations in proteins that control chromatin dynamics contribute to tumorigenesis.</jats:p>

<jats:p>A technique is demonstrated that allows single layers of graphene to be removed one layer at a time.</jats:p>

<jats:p>A large complex of type III protein secretion system components helps bacteria to invade their hosts.</jats:p>

<jats:p>Vector-borne parasites cause major human diseases of the developing world, including malaria, human African trypanosomiasis, Chagas disease, leishmaniasis, filariasis, and schistosomiasis. Although the life cycles of these parasites were defined over 100 years ago, the strategies they use to optimize their successful transmission are only now being understood in molecular terms. Parasites are now known to monitor their environment in both their host and vector and in response to other parasites. This allows them to adapt their developmental cycles and to counteract any unfavorable conditions they encounter. Here, I review the interactions that parasites engage in with their hosts and vectors to maximize their survival and spread.</jats:p>

<jats:title>Sizing Signals</jats:title> <jats:p> Growth regulation of the <jats:italic>Drosophila</jats:italic> wing imaginal disc critically depends on the Decapentaplegic (Dpp) morphogen gradient. How a graded Dpp signal is interpreted by cells to control homogeneous tissue growth remains unclear. <jats:bold> Wartlick <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="1154" related-article-type="in-this-issue" vol="331" xlink:href="10.1126/science.1200037">1154</jats:related-article> ; see the Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6021" page="1141" related-article-type="in-this-issue" vol="331" xlink:href="10.1126/science.1203270"> <jats:bold>Le Goff and Lecuit</jats:bold> </jats:related-article> ) address this question by measuring the spatial and temporal changes of Dpp concentration and signaling activity during the disc growth phase and by quantifying cell proliferation parameters in the discs. Both modeling and experimental findings suggest that both Dpp concentration and signaling gradients scale with tissue size so that, on average, the onset of mitosis occurs when Dpp signaling levels have increased by 50% since the beginning of the cell cycle. </jats:p>

<jats:p>The structure reveals the functional elements of the dynein motor and suggests how they change conformation during motility.</jats:p>

<jats:p>Optical fields have been manipulated like radio frequencies into sawtooth and square-wave patterns.</jats:p>