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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

Verificá que desde tu institución tengas acceso para descargar o solicitar el libro completo o alguno de sus capítulos.

doi: 10.1126/science.1208130

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

Nicolas Stransky; Ann Marie Egloff; Aaron D. Tward; Aleksandar D. Kostic; Kristian Cibulskis; Andrey Sivachenko; Gregory V. Kryukov; Michael S. Lawrence; Carrie Sougnez; Aaron McKenna; Erica Shefler; Alex H. Ramos; Petar Stojanov; Scott L. Carter; Douglas Voet; Maria L. Cortés; Daniel Auclair; Michael F. Berger; Gordon Saksena; Candace Guiducci; Robert C. Onofrio; Melissa Parkin; Marjorie Romkes; Joel L. Weissfeld; Raja R. Seethala; Lin Wang; Claudia Rangel-Escareño; Juan Carlos Fernandez-Lopez; Alfredo Hidalgo-Miranda; Jorge Melendez-Zajgla; Wendy Winckler; Kristin Ardlie; Stacey B. Gabriel; Matthew Meyerson; Eric S. Lander; Gad Getz; Todd R. Golub; Levi A. Garraway; Jennifer R. Grandis

<jats:p>The mutational profile of head and neck cancer is complex and may pose challenges to the development of targeted therapies.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1157-1160

doi: 10.1126/science.1206638

MED23 Mutation Links Intellectual Disability to Dysregulation of Immediate Early Gene Expression

Satoru Hashimoto; Sarah Boissel; Mohammed Zarhrate; Marlène Rio; Arnold Munnich; Jean-Marc Egly; Laurence Colleaux

<jats:p>A single missense mutation is linked to intellectual impairment.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1161-1163

doi: 10.1126/science.333.6046.1164

LIFE SCIENCE TECHNOLOGIES: Protein Chemistry: Getting Above The Fold

Alan Dove

<jats:p>Fifty years ago, biochemist Christian Anfinsen denatured some pure globular proteins, and observed that they refolded into their proper three-dimensional shapes without assistance, demonstrating that the amino acid sequence alone provides all of the information necessary to direct the folding of at least certain proteins. All researchers had to do was figure out the rules for that process, and they would be able to predict any structure from the protein's sequence.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1164-1166

doi: 10.1126/science.333.6046.1167-a

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1167-1167

doi: 10.1126/science.333.6046.1167-b