Catálogo de publicaciones - revistas

<jats:title>Exponential Growth Effects</jats:title> <jats:p> Humans are an extraordinarily successful species, as measured by our large population size—approximately 7 billion—much of which can be put down to recent explosive growth. Leveraging human genomic data, <jats:bold>Keinan and Clark</jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="740" related-article-type="in-this-issue" vol="336" xlink:href="10.1126/science.1217283">740</jats:related-article> ) examined the effects of population growth on our ability to detect rare genetic variants, those hypothesized to be most likely associated with disease. It appears that rapid recent growth increases the load of rare variants and is likely to play an important role in the individual genetic burden of complex disease risk. </jats:p>

<jats:title>Silence, Please</jats:title> <jats:p> Polycomb group (PcG) proteins play pivotal roles in epigenetic gene control, development, and disease. PcG proteins can control cell cycle progression, but the underlying mechanisms remain unclear. PcG proteins are thought to silence transcription of target genes through modulating chromatin structure. <jats:bold> Mohd-Sarip <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="744" related-article-type="in-this-issue" vol="336" xlink:href="10.1126/science.1215927">744</jats:related-article> , published online 5 April) uncovered an unanticipated transcription-independent function for the canonical PcG protein “Posterior sex combs” in cell cycle control, through its direct regulation of cyclin B destruction. </jats:p>

<jats:p>When it comes to 'omics-inspired bioscience tools, next-gen DNA sequencing is the undisputed king. The previous champ was the DNA microarray, with the protein array its logical successor. Yet while DNA arrays achieved their potential, protein arrays never really took off, owing largely to the fact that, while every DNA oligo behaves more or less identically, the same cannot be said of proteins. They're also harder to synthesize, purify, and stabilize. Still, to paraphrase Mark Twain, the rumor of protein array's death has been greatly exaggerated. Today, new array formats and strategies have made the protein microarray a viable and growing tool for biomarker discovery, interactome research, functional genomics, and more.</jats:p>

<jats:p>The show includes Mayan astronomical tables from the 9th century, cosmic insights from Vesta, a fossilized forest in China, and more.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>