Catálogo de publicaciones - revistas

<jats:p>A long-awaited transporter that moves pyruvate into mitochondria has been identified.</jats:p>

<jats:p>Observations reveal the possible formation of a brown dwarf through the collapse of an interstellar cloud fragment.</jats:p>

<jats:p>The crystal structure of a Wnt-Frizzled complex uncovers an unusual interaction mode, with a lipid in the binding interface holding the complex together.</jats:p>

<jats:p>Observational and modeling studies probe the causes and consequences of the spring bloom of phytoplankton.</jats:p>

<jats:p>Cell proliferation experiments suggest that cancer can gain an advantage by partially inactivating several genes simultaneously with single deletion events.</jats:p>

<jats:title>Network, Network, Network</jats:title> <jats:p> The fact that our interactions with others influence many of our decisions has led to research on characterizing the networks to which we belong and, more recently, on interventions that can change networks thereby changing behavior. This can have a variety of purposes, including promoting information flow through an organization or finding vulnerable points in bioterrorist networks. <jats:bold>Valente</jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="49" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1217330">49</jats:related-article> ) reviews a variety of strategies for affecting networks. </jats:p>

<jats:title>Early Bloom Trigger</jats:title> <jats:p> Springtime phytoplankton blooms occur when high nutrient concentrations are combined with abundant sunlight and a stratified upper ocean layer. It has been thought that stratification occurs because in the spring, seasonal warming causes the water to expand, making it less dense, which creates a layer resistant to mixing from below. Now, <jats:bold> Mahadevan <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="54" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1218740">54</jats:related-article> ; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6090" page="46" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1223881">Martin</jats:related-article> </jats:bold> ) have combined observations of the upper water column from the subpolar North Atlantic with ocean model simulations, which demonstrate that the initial stratification can be triggered by the dynamic effects of passing ocean eddies. These eddies can advance the time of the bloom by 20 to 30 days. </jats:p>

<jats:title>Dissecting Wnt/Fz Interaction</jats:title> <jats:p> Wnt proteins activate the transmembrane receptor Frizzled (Fz) to initiate pathways central to vertebrate and invertebrate development. Wnts are palmitoylated, which has complicated structural and functional characterization. <jats:bold> Janda <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="59" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1222879">59</jats:related-article> , published online 31 May; see the Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6090" page="44" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1224468"> <jats:bold>Bienz and He</jats:bold> </jats:related-article> ) achieved coexpression and purification of <jats:italic>Xenopus</jats:italic> Wnt8 (XWnt8) with mouse Fz8 cysteine rich domain (CRD) and determined a crystal structure of the complex. Wnt binds to the Fz8 CRD at two distinct sites with the lipid group playing a key role in the first interface. Both interfaces involve conserved amino acids, which may explain the known pleiotropy of the Wnt/Fz interaction. </jats:p>

<jats:title>A Deep Look Into Our Genes</jats:title> <jats:p> Recent debates have focused on the degree of genetic variation and its impact upon health at the genomic level in humans (see the Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6090" page="39" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1224528"> <jats:bold>Casals and Bertranpetit</jats:bold> </jats:related-article> ). <jats:bold> Tennessen <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="64" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1219240">64</jats:related-article> , published online 17 May), looking at all of the protein-coding genes in the human genome, and <jats:bold> Nelson <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="100" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1217876">100</jats:related-article> , published online 17 May), looking at genes that encode drug targets, address this question through deep sequencing efforts on samples from multiple individuals. The findings suggest that most human variation is rare, not shared between populations, and that rare variants are likely to play a role in human health. </jats:p>

<jats:title>A Dwarf in the Making</jats:title> <jats:p> It is a mystery how brown dwarfs, which have masses in between those of planets and stars, form. Based on observations with the Institut de Radioastronomie Millimétrique Plateau de Bure Interferometer, located in the French Alps, <jats:bold> André <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="69" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1222602">69</jats:related-article> ; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6090" page="43" related-article-type="in-this-issue" vol="337" xlink:href="10.1126/science.1224342">Basu</jats:related-article> </jats:bold> ) report the detection of a brown dwarf that is still in the process of forming. The results lend support to models that suggest that brown dwarfs form in the same way as nuclear-burning stars, like our Sun, but do not rule out other models. </jats:p>