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Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Neandertal Champion Defends the Reputation of Our Closest Cousins
Michael Balter
<jats:p>Archaeologist João Zilhão and his critics trade charges over who truly invented artifacts at European sites—and whether Neandertals were “modern.â€</jats:p>
Palabras clave: Multidisciplinary.
Pp. 642-643
Predicting the Next Influenza Virus
Scott Krauss; Robert G. Webster
Palabras clave: Multidisciplinary.
Pp. 644-644
Steps Forward for Greece
Nikolaos M. Stavrakakis; Ioannis Tsaknis; Maria Th. Stoumboudi
Palabras clave: Multidisciplinary.
Pp. 644-645
Mainstreaming Systems Science
Paul Dargusch; Carl Smith
Palabras clave: Multidisciplinary.
Pp. 645-645
Comment on “Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibitionâ€
Stefan Löffler; Jochen Körber; Udo Nubbemeyer; Karin Fehsel
<jats:p> Ray <jats:italic>et al</jats:italic> . (Reports, 29 July 2011, p. 637) assume that clozapine- <jats:italic>N</jats:italic> 4-oxide (CNO) represents a “biologically inert synthetic ligand†that selectively activates the M4 muscarinic receptor-based DREADD (designer receptor exclusively activated by a designer drug). In contrast, due to the redox cycling of CNO with clozapine and to their cell membrane permeability, CNO is biologically active and its conversion products are capable of undermining DREADD effects. </jats:p>
Palabras clave: Multidisciplinary.
Pp. 646-646
Corrections and Clarifications
Palabras clave: Multidisciplinary.
Pp. 646-646
Response to Comment on “Impaired Respiratory and Body Temperature Control Upon Acute Serotonergic Neuron Inhibitionâ€
Susan M. Dymecki; Russell R. Ray; Rachael D. Brust; Andrea E. Corcoran; Jun Chul Kim; George B. Richerson; Eugene Nattie
<jats:p> Löffler <jats:italic>et al</jats:italic> . highlight the important potential of designer receptors exclusively activated by a designer drug (DREADD)–based technologies to study cell type–specific functions but cautions that the triggering DREADD ligand, clozapine- <jats:italic>N</jats:italic> -oxide (CNO) might, through potential conversion products, have bioactivity outside of the synthetic DREADD receptor system and maintains that Ray <jats:italic>et al</jats:italic> . did not control for such activity. We recount controls used in our work that indicated no discernible DREADD-independent effects of CNO on the homeostatic assays employed and discuss in this regard murine studies reporting CNO bioneutrality in other assays, the rapid renal clearance of N-oxides like CNO, and evidence of negligible conversion to clozapine (CN) in mice and rats. </jats:p>
Palabras clave: Multidisciplinary.
Pp. 646-647
Preempting Pandemics The Viral Storm The Dawn of a New Pandemic Age by Nathan Wolfe Times Books (Holt), New York, 2011. 315 pp. $26, C$30. ISBN 9780805091946.
Barbara A. Han; Julie Rushmore; Alexa Fritzsche; Dara Satterfield; Jamie Winternitz
<jats:p>After reviewing the threats posed by undiscovered viruses, Wolfe holds out hope that impressive advances in surveillance may help us avoid future pandemics.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 647-648
Improving the Prospects Breaking into the Lab Engineering Progress for Women in Science by Sue V. Rosser New York University Press, New York, 2012. 261 pp. $3
Kristen Andersen
<jats:p>Rosser uses interviews with successful female scientists to explore ways to surmount the hurdles that women in science continue to face.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 648-648