Catálogo de publicaciones - revistas

<jats:p>Identification of a postsynaptic protein in the hippocampus reveals how neurotransmitter release from one neuron is tailored to different target cells.</jats:p>

<jats:p>Continually refining the focus of intellectual property during the drug development process should encourage productive collaborations and expedite the availability of new therapies.</jats:p>

<jats:p>Endophyte Discovery, an IBI Prize–winning module, allows novice scientists to engage in meaningful discovery through inquiry-based research experiences.</jats:p>

<jats:p>Worm Mutants, an IBI Prize–winning module, offers Biology majors the opportunity to identify mutants and learn about genes that regulate biological functions.</jats:p>

<jats:p> A monthly roundup of recent news and projects of <jats:italic>Science</jats:italic> 's publisher, the American Association for the Advancement of Science. </jats:p>

<jats:p>The diseases of myelin are among the most prevalent and disabling conditions in neurology. These diseases include both the vascular and inflammatory demyelinating disorders of adulthood, as well as the childhood leukodystrophies and cerebral palsy. These fundamentally glial disorders may be amenable to treatment by glial progenitor cells (GPCs), which give rise to astroglia and myelin-producing oligodendrocytes. Given the development of new methods for generating and isolating human GPCs, the myelin disorders may now be compelling targets for cell-based therapy. In addition, the efficient engraftment and expansion of human GPCs in murine hosts has led to the development of human glial chimeric mouse brains, which provides new opportunities for studying the species-specific roles of human glia in cognition, as well as in disease pathogenesis.</jats:p>

<jats:title>Cause or Correlation?</jats:title> <jats:p> Three centuries ago, Bishop Berkeley's 1710 classic “A treatise on the nature of human knowledge,” first spelled out the “correlation vs. causation” dilemma. <jats:bold> Sugihara <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="496" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1227079">496</jats:related-article> , published online 20 September) present an approach to this conundrum, and extend current discussions about causation to dynamic systems with weak to moderate coupling (such as ecosystems). The resulting method, convergent cross mapping can detect causal linkages between time series. </jats:p>

<jats:title>Forced Asymmetry in Cp</jats:title> <jats:p> The cyclopentadienyl (Cp) ligand—a pentagon of carbons—is a common feature in transition metal catalysts, but chiral variants of the structure have rarely been applied to asymmetric reactions. Two studies now demonstrate distinct approaches to rendering a Cp-derived rhodium catalyst enantioselective in a tandem carbon-hydrogen activation-ring closure reaction that couples olefins with benzamides (see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6106" page="479" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1229830">Wang and Glorius</jats:related-article> ). Hyster <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="500" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1226132">500</jats:related-article> ) tethered a biotin derivative to the Cp ligand to enable docking in a chiral streptavidin protein cavity, which in turn was engineered to further optimize catalytic performance. <jats:bold>Ye and Cramer</jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="504" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1226938">504</jats:related-article> ) appended chiral substituents on the Cp framework to bias the rest of the coordination environment around the metal center. </jats:p>

<jats:title>Forced Asymmetry in Cp</jats:title> <jats:p> The cyclopentadienyl (Cp) ligand—a pentagon of carbons—is a common feature in transition metal catalysts, but chiral variants of the structure have rarely been applied to asymmetric reactions. Two studies now demonstrate distinct approaches to rendering a Cp-derived rhodium catalyst enantioselective in a tandem carbon-hydrogen activation-ring closure reaction that couples olefins with benzamides (see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6106" page="479" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1229830">Wang and Glorius</jats:related-article> ). Hyster <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="500" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1226132">500</jats:related-article> ) tethered a biotin derivative to the Cp ligand to enable docking in a chiral streptavidin protein cavity, which in turn was engineered to further optimize catalytic performance. <jats:bold>Ye and Cramer</jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="504" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1226938">504</jats:related-article> ) appended chiral substituents on the Cp framework to bias the rest of the coordination environment around the metal center. </jats:p>

<jats:title>Building a Fluorescent Hotspot</jats:title> <jats:p> When two gold nanoparticles come close together, their overlapping plasmonic fields can create a region that acts as a nanoantenna that can enhance the fluorescent emission of a molecule. <jats:bold> Acuna <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" page="506" related-article-type="in-this-issue" vol="338" xlink:href="10.1126/science.1228638">506</jats:related-article> ) used a surface-anchored DNA origami structure to assemble one or two gold nanoparticles next to a dye trapped within the structure. A &gt; 100-fold enhancement in fluorescent emission was observed when the dye molecules were located in a 23-nm gap between two 100-nm gold nanoparticles. </jats:p>