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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

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Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

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doi: 10.1126/science.1232627

Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity

Sheng-Jia Zhang; Jing Ye; Chenglin Miao; Albert Tsao; Ignas Cerniauskas; Debora Ledergerber; May-Britt Moser; Edvard I. Moser

<jats:title>From Grid to Place</jats:title> <jats:p> Grid cells are considered one of the key sources for place-cell signals in the hippocampus. The entorhinal circuit also contains other functional cell types, but it is unclear which project to the place cells of the hippocampus. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1232627"> <jats:bold> Zhang <jats:italic>et al.</jats:italic> </jats:bold> </jats:related-article> (10.1126/science.1232627, see the Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6128" page="35" related-article-type="in-this-issue" vol="340" xlink:href="10.1126/science.1237567"> <jats:bold>Poucet and Sargolini</jats:bold> </jats:related-article> ) addressed this question using optogenetics and in vivo multi-electrode electrophysiology. Hippocampal cells received input from a broad spectrum of entorhinal neuronal cell types. Grid cells represented the biggest group of spatial inputs, but border cells, head-direction cells, and a large fraction of nonspatial cells also provided inputs. Thus, hippocampal circuits have local mechanisms for processing specific types of functional input from the entorhinal cortex to generate place-specific signals. </jats:p>