Catálogo de publicaciones - revistas

<jats:p> Cramer <jats:italic>et al</jats:italic> . (Reports, 23 March 2012, p. 1503; published online 9 February 2012) reported that bexarotene rapidly reduces β-amyloid (Aβ) levels and plaque burden in two mouse models of Aβ deposition in Alzheimer’s disease (AD). We now report that, although bexarotene reduces soluble Aβ <jats:sub>40</jats:sub> levels in one of the mouse models, the drug has no impact on plaque burden in three strains that exhibit Aβ amyloidosis. </jats:p>

<jats:p> Cramer <jats:italic>et al</jats:italic> . (Reports, 23 March 2012, p. 1503; published online 9 February 2012) demonstrated in a mouse model for Alzheimer’s disease (AD) that treatment of APP/PS1ΔE9 mice with bexarotene decreased Aβ pathology and ameliorated memory deficits. We confirm the reversal of memory deficits in APP/PS1ΔE9 mice expressing human APOE3 or APOE4 to the levels of their nontransgenic controls and the significant decrease of interstitial fluid Aβ, but not the effects on amyloid deposition. </jats:p>

<jats:p> Cramer <jats:italic>et al</jats:italic> . (Reports, 23 March 2012, p. 1503; published online 9 February 2012) tested bexarotene as a potential β-amyloid–lowering drug for Alzheimer’s disease (AD). We were not able to reproduce the described effects in several animal models. Drug formulation appears very critical. Our data call for extreme caution when considering this compound for use in AD patients. </jats:p>

<jats:p> A <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/site/feature/data/books/brl6135.xhtml">listing of books received</jats:ext-link> at <jats:italic>Science</jats:italic> during the week ending 17 May 2013. </jats:p>

<jats:p>Vicedo's examination of the history of attachment theory and the concept of "mother love" illustrates the impact prevailing preconceptions have on efforts to draw social lessons from biology.</jats:p>

<jats:p>Field-based evidence suggests that guidelines against economic rewards to motivate blood donors should be reconsidered.</jats:p>

<jats:p>Genetic evolution may have been driven by cultural innovations during the emergence of modern humans.</jats:p>

<jats:p> Proteins that take too long to fold are tagged with sugar to stop their failed attempts and remove them from the cell's folding compartment. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6135" page="978" related-article-type="in-this-issue" vol="340" xlink:href="10.1126/science.1234055"> Xu <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p> Accurate distances to compact binary stars help establish a clear understanding of accretion disk evolution. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6135" page="950" related-article-type="in-this-issue" vol="340" xlink:href="10.1126/science.1237145"> Miller-Jones <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>