Catálogo de publicaciones - revistas

<jats:p>There's a lot of high-tech equipment in today's clinical laboratory. Microscopes and histology stains are sharing bench-space with flow cytometers and microfluidic processors, DNA sequencers, and microarray readers—and mass spectrometers. Long the province of chemists and proteomicists, mass spectrometry has more recently established itself as a bona fide clinical tool. Now a new application is heading to the clinic, mass spec imaging.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>The importance of food safety and security in today's global economy cannot be ignored. China has recognized that advances in agricultural science and technology are essential in order to continue to feed its growing population.</jats:p> <jats:p>CAAS, the Chinese Academy of Agricultural Sciences, is leading the effort to keep China ahead of the curve by growing itself into a top, world-class institution that can support the future needs of a developing nation. In this booklet, we look into some of the programs and institutes that CAAS oversees to gain some insight into how the future of agriculture in China might look.</jats:p>

<jats:p>Listen to stories on putting graphene's strength to the test, radiation on the way to Mars, alleviating India's poverty through science, and more.</jats:p>

<jats:title>Collinearity Cracked in Tetrapod Limbs</jats:title> <jats:p> During limb development, the time a nd place of <jats:italic>Hox</jats:italic> transcription are fixed by respective gene position within the gene cluster. <jats:bold> Andrey <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/340/6137/1234167.full">1234167</jats:ext-link> ; see the Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6137" page="1181" related-article-type="in-this-issue" vol="340" xlink:href="10.1126/science.1239867"> <jats:bold>Rodrigues and Tabin</jats:bold> </jats:related-article> ) found that this enigmatic property results from the opposite and successive actions of two large regulatory landscapes located on either side of the mouse <jats:italic>Hox</jats:italic> locus. In the early phase, one of these topological domains regulates transcription in the proximal limb until a switch occurs toward the other topological domain, which takes over the regulation in the distally developing digits. As a side effect of this antagonistic regulatory strategy, cells in-between have lessened <jats:italic>Hox</jats:italic> transcription, which generates the wrist. </jats:p>

<jats:p>Morphogenesis, the development of the shape of an organism, is a dynamic process on a multitude of scales, from fast subcellular rearrangements and cell movements to slow structural changes at the whole-organism level. Live-imaging approaches based on light microscopy reveal the intricate dynamics of this process and are thus indispensable for investigating the underlying mechanisms. This Review discusses emerging imaging techniques that can record morphogenesis at temporal scales from seconds to days and at spatial scales from hundreds of nanometers to several millimeters. To unlock their full potential, these methods need to be matched with new computational approaches and physical models that help convert highly complex image data sets into biological insights.</jats:p>