Catálogo de publicaciones - revistas

<jats:p>Alfred Russel Wallace's science of distribution provided the foundation of biogeography.</jats:p>

<jats:p> Macrophages respond to bacteria through a protein complex that promotes inflammation when activated by internalized bacterial endotoxin. <jats:named-content content-type="related-content"> [Also see Reports by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6151" page="1246" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1240248"> Kayagaki <jats:italic>et al.</jats:italic> </jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6151" page="1250" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1240988"> Hagar <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p> Improvements in the stability of atomic clocks could enable local gravity measurements and tests of fundamental physics. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6151" page="1215" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1240420"> Hinkley <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p>Much remains to be learned about CTCs and their clinical potential as biomarkers and therapeutic targets.</jats:p>

<jats:p> The emergence of density fluctuations in a cloud of interacting cold atoms shows characteristic aspects of the evolution of the early universe. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6151" page="1213" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1237557"> Hung <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p>In a relatively short period of time, monoclonal antibodies have entered the mainstream of cancer therapy. Their first use was as antagonists of oncogenic receptor tyrosine kinases, but today monoclonal antibodies have emerged as long-sought vehicles for the targeted delivery of potent chemotherapeutic agents and as powerful tools to manipulate anticancer immune responses. With ever more promising results from the clinic, the future will likely see continued growth in the discovery and development of therapeutic antibodies and their derivatives.</jats:p>

<jats:p>Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope for a protective immunization. Renewed optimism in this area of research comes in part from the results of a recent vaccine trial and the use of single-cell antibody-cloning techniques that uncovered naturally arising, broad and potent HIV-1–neutralizing antibodies (bNAbs). These antibodies can protect against infection and suppress established HIV-1 infection in animal models. The finding that these antibodies develop in a fraction of infected individuals supports the idea that new approaches to vaccination might be developed by adapting the natural immune strategies or by structure-based immunogen design. Moreover, the success of passive immunotherapy in small-animal models suggests that bNAbs may become a valuable addition to the armamentarium of drugs that work against HIV-1.</jats:p>

<jats:p>Immunological memory is the residuum of a successful immune response that in the B cell lineage comprises long-lived plasma cells and long-lived memory B cells. It is apparent that distinct classes of memory B cells exist, distinguishable by, among other things, immunoglobulin isotype, location, and passage through the germinal center. Some of this variation is due to the nature of the antigen, and some appears to be inherent to the process of forming memory. Here, we consider the heterogeneity in development and phenotype of memory B cells and whether particular functions are partitioned into distinct subsets. We consider also how understanding the details of generating memory may provide opportunities to develop better, functionally targeted vaccines.</jats:p>

<jats:title>Tinyverse</jats:title><jats:p>Quantum many-systems, such superfluids, are difficult to study in equilibrium, and thus understanding their dynamics poses a particular challenge. When the strength of interactions was suddenly changed in a two-dimensional gas of cesium atoms,<jats:bold>Hung<jats:italic>et al.</jats:italic></jats:bold>(p.<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6151" page="1213" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1237557">1213</jats:related-article>, published online 1 August; see the Perspective by<jats:related-article issue="6151" page="" related-article-type="in-this-issue" vol="341"><jats:bold>Schmiedmayer and Berges</jats:bold></jats:related-article>) observed oscillations in the time and space domains analogous to the peaks in the spectrum of the cosmic microwave background.</jats:p>