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Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Books Received
<jats:p> A <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/site/feature/data/books/brl6152.xhtml">listing of books received</jats:ext-link> at <jats:italic>Science</jats:italic> during the week ending 13 September 2013. </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1344-1344
Mitochondrial Replacement, Evolution, and the Clinic
Klaus Reinhardt; Damian K. Dowling; Edward H. Morrow
<jats:p>Mitochondrial replacement therapy might bear health risks, especially for males.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1345-1346
A New Bundle of Prospects for Blocking HIV-1 Entry
P. J. Klasse
<jats:p> A crystal structure of the HIV-1 co-receptor CCR5 with a bound inhibitor may assist the rational improvement of small-molecule inhibitors. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6152" page="1387" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1241475"> Tan <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1347-1348
Lewis Acids with a Difference
François P. Gabbaï
<jats:p> A fluorinated phosphorus Lewis acid may find application in fluorocarbon remediation. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6152" page="1374" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1241764"> Caputo <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1348-1349
Concentrating (on) Native Proteins to Control Cell Fate
Casim A. Sarkar
<jats:p> Synthetic genetic controllers modulate endogenous signaling networks to route cells toward desired behaviors. <jats:named-content content-type="related-content"> [Also see Research Article by <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/341/6152/1235005.full"> Galloway <jats:italic>et al.</jats:italic> </jats:ext-link> ] </jats:named-content> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1349-1351
Polymers Find Plenty of Wiggle Room at the Bottom
Thomas P. Russell
<jats:p> The glassy dynamics of an isolated polymer chain is found to be identical to that of a bulk material. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6152" page="1371" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1238950"> Tress <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1351-1352
Pasteur Approach to a Malaria Vaccine May Take the Lead
Michael F. Good
<jats:p> A rationalized and reinvented approach to vaccinating against malaria shows impressive results. <jats:named-content content-type="related-content"> [Also see Research Article by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6152" page="1359" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1241800"> Seder <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1352-1353
Promiscuous Alzheimer's Amyloid: Yet Another Partner
Iryna Benilova; Bart De Strooper
<jats:p> A neuroimmune receptor has high affinity for Alzheimer's β-amyloid aggregates and mediates a synaptotoxic cascade in neurons. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6152" page="1399" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1242077"> Kim <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1354-1355
Causes of the Cambrian Explosion
M. Paul Smith; David A. T. Harper
<jats:p>The rapid diversification of animal species in the early Cambrian was the result of a range of interacting biotic and abiotic processes.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1355-1356
Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
Robert A. Seder; Lee-Jah Chang; Mary E. Enama; Kathryn L. Zephir; Uzma N. Sarwar; Ingelise J. Gordon; LaSonji A. Holman; Eric R. James; Peter F. Billingsley; Anusha Gunasekera; Adam Richman; Sumana Chakravarty; Anita Manoj; Soundarapandian Velmurugan; MingLin Li; Adam J. Ruben; Tao Li; Abraham G. Eappen; Richard E. Stafford; Sarah H. Plummer; Cynthia S. Hendel; Laura Novik; Pamela J. M. Costner; Floreliz H. Mendoza; Jamie G. Saunders; Martha C. Nason; Jason H. Richardson; Jittawadee Murphy; Silas A. Davidson; Thomas L. Richie; Martha Sedegah; Awalludin Sutamihardja; Gary A. Fahle; Kirsten E. Lyke; Matthew B. Laurens; Mario Roederer; Kavita Tewari; Judith E. Epstein; B. Kim Lee Sim; Julie E. Ledgerwood; Barney S. Graham; Stephen L. Hoffman; Cassandra DiGiovanni; Pernell Williams; Nicole Luongo; Jillian Mitchell; Maria Burgos Florez; Brenda Larkin; Nina Berkowitz; Brandon Wilson; Tanya Clarke; Olga Vasilenko; Galina Yamshchikov; Sandra Sitar; LaChonne Stanford; Iris Pittman; Robert T. Bailer; Joseph Casazza; Hope Decederfelt; Judith Starling; Esther C. Williams; Anna Lau; Stella Antonara; Jeffery Brocious; Margaret Kemp; James Inglese; Patricia Dranchak; Esteban N. Abot; Sharina Reyes; Harini Ganeshan; Maria Belmonte; Jun Huang; Arnel Belmonte; Jack Komisar; Yonas Abebe; Yeab Getachew; Asha Patil; Steve Matheny; Keith Nelson; James Overby; Virak Pich; Yingda Wen; Richard Fan; Enni Fomumbod; Aderonke Awe; Chinnamma Chakiath; Mary King; Maria Socorro Orozco; Tooba Murshedkar; Debbie Padilla; Bing Jiang; Lixin Gao; Natasha KC; Rui Xu; Matthew Adams; Christopher Plowe; Hayley Loblein; Phyllis Zaia Renehan; Meghan Kunchai; Ly Diep;
<jats:title>Malaria Sporozoite Vaccine</jats:title> <jats:p> Each year, hundreds of millions of people are infected with <jats:italic>Plasmodium falciparum</jats:italic> , the mosquito-borne parasite that causes malaria. A preventative vaccine is greatly needed. <jats:bold> Seder <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6152" page="1359" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1241800">1359</jats:related-article> , published online 8 August; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6152" page="1352" related-article-type="in-this-issue" vol="341" xlink:href="10.1126/science.1244157">Good</jats:related-article> </jats:bold> ) now report the results from a phase I clinical trial where subjects were immunized intravenously with a whole, attenuated sporozoite vaccine. Three of 9 subjects who received four doses and zero of 6 subjects who received five doses of the vaccine went on to develop malaria after controlled malaria infection. Both antibody titers and cellular immune responses correlated positively with the dose of vaccine received, suggesting that both arms of the adaptive immune response may have participated in the observed protection. </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1359-1365