Catálogo de publicaciones - revistas

<jats:title>Command and Control</jats:title> <jats:p> Innate lymphoid cells are vital for the development of gut-associated lymphoid tissues, maintenance of the epithelial barrier, and protection against intestinal microbes; their dysfunction can promote immune pathology. Immunoglobulin A (IgA) production is important for maintenance of the gut epithelial barrier and the composition of the gut microbiota. Through the generation of knockout mouse models, <jats:bold> Kruglov <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6163" page="1243" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1243364">1243</jats:related-article> ) were able to distinguish how soluble and membrane-bound lymphotoxins expressed by innate lymphoid cells in the gut specifically regulate IgA production and thereby control gut microbiota composition. </jats:p>

<jats:title>Hedgehog View to a Kill</jats:title> <jats:p> Hedgehog (Hh) signaling is best known for its role in development and is a key signaling component of primary cilia. Hh signaling plays a role in T cell development, but whether Hh signaling plays a role in the function of mature effector T cells is unclear. <jats:bold> De la Roche <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6163" page="1247" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1244689">1247</jats:related-article> ; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6163" page="1177" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1248078">Le Borgne and Shaw</jats:related-article> </jats:bold> ) now show that T cell receptor signaling triggers Hh signaling. When Hh signaling is disrupted, centrosome polarization to the immunological synapse is reduced, and cytotoxic T cell–mediated killing is impaired. </jats:p>

<jats:title>Good Foundations, Poor Access</jats:title> <jats:p> Dyslexia makes reading and spelling difficult. <jats:bold> Boets <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6163" page="1251" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1244333">1251</jats:related-article> ) analyzed whether for adult readers with dyslexia the internal references for word sounds are poorly constructed or whether accessing those references is abnormally difficult. Brain imaging during phonetic discrimination tasks suggested that the internal dictionary for word sounds was correct, but accessing the dictionary was more difficult than normal. </jats:p>

<jats:title>Not Too Much, Not Too Little</jats:title> <jats:p> The microRNA miR128 is expressed in brain neurons of the mouse. <jats:bold> Lek Tan <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6163" page="1254" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1244193">1254</jats:related-article> ) now find that miR128 is crucial to stable brain function. Mice deficient in miR128 developed hyperactivity and were susceptible to fatal seizures, whereas overexpression of miR128 correlated with reduced motor activity and reduced susceptibility to proconvulsive drugs. Experiments using ex vivo–isolated adult brain tissues suggested that miR-128 controlled motor activity by governing the signaling network that determines the intrinsic excitability and signal responsiveness of neurons. </jats:p>

<jats:p>Traditional laboratory biology is a small-scale operation; tissue culture dishes are seldom much larger than the experimenter's hand, volume measurements are in milliliters, and a protein purification that yields a few micrograms is a success. With burgeoning interest in translational research, structural biology, and regenerative medicine, many scientists are starting to think bigger. Whether trying to purify grams of protein for crystallography or testing the feasibility of turning a novel gene product into a new drug, these researchers soon find themselves pondering the complications of larger-scale cell culture.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Listen to stories on noisy gene expression, results from drilling at the Tohoku-Oki fault, the benefits of snake venom, and more.</jats:p>