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<jats:p> Researchers announced they had derived stem cells from cloned human embryos, a long-awaited research coup that <jats:italic>Science</jats:italic> 's editors chose as a runner-up for Breakthrough of the Year. </jats:p>

<jats:p> In research that <jats:italic>Science</jats:italic> 's editors chose as a runner-up for Breakthrough of the Year, scientists coaxed cells called pluripotent stem cells to grow into tiny "organoids"—liver buds, mini-kidneys, and even rudimentary human brains—in the lab. </jats:p>

<jats:p> Up-and-coming solar cell materials called perovskites made such rapid progress this year that the editors of <jats:italic>Science</jats:italic> picked them as a runner-up for Breakthrough of the Year. </jats:p>

<jats:p> This year, astronomers traced high-energy particles called cosmic rays back to their birthplaces in the debris clouds of supernovae—a feat that <jats:italic>Science</jats:italic> 's editors chose as a runner-up for Breakthrough of the Year <jats:italic>.</jats:italic> </jats:p>

<jats:p> In work that <jats:italic>Science</jats:italic> 's editors named a runner-up for Breakthrough of the Year, researchers studying mice have found experimental evidence that sleep helps to restore and repair the brain. </jats:p>

<jats:p> Researchers have found that bacteria living inside the human body play vital roles in determining how the body responds to challenges as different as malnutrition and cancer—a realization that <jats:italic>Science</jats:italic> 's editors named a runner-up for Breakthrough of the Year. </jats:p>

<jats:p> <jats:italic>Science</jats:italic> editors rate how well they predicted scientific areas worth watching in 2013. </jats:p>

<jats:p> In work that <jats:italic>Science</jats:italic> ranked as a runner-up for Breakthrough of the Year, researchers used structural biology—the study of the molecules of life—to design the key ingredient of a vaccine against a dangerous childhood disease. </jats:p>

<jats:p> <jats:italic>Science</jats:italic> editors forecast science news to look out for in the year ahead. </jats:p>

<jats:p> Find out what <jats:italic>Science</jats:italic> staff considered the top breakup, breakdowns, breakout, and genomes of the year, as well as 2013's top fossil, politico, vertebrate, and invertebrate. </jats:p>