Catálogo de publicaciones - revistas

<jats:title>Shaping Plant Evolution</jats:title> <jats:p> <jats:italic>Amborella trichopoda</jats:italic> is understood to be the most basal extant flowering plant and its genome is anticipated to provide insights into the evolution of plant life on Earth (see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6165" page="1456" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1248709">Adams</jats:related-article> </jats:bold> ). To validate and assemble the sequence, <jats:bold> Chamala <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6165" page="1516" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1241130">1516</jats:related-article> ) combined fluorescent in situ hybridization (FISH), genomic mapping, and next-generation sequencing. The <jats:bold>Amborella Genome Project</jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1241089">10.1126/science.1241089</jats:related-article> ) was able to infer that a whole-genome duplication event preceded the evolution of this ancestral angiosperm, and <jats:bold> Rice <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6165" page="1468" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1246275">1468</jats:related-article> ) found that numerous genes in the mitochondrion were acquired by horizontal gene transfer from other plants, including almost four entire mitochondrial genomes from mosses and algae. </jats:p>

<jats:title>Ubiquitin Fertility Insurance</jats:title> <jats:p> The female mammal's reproductive lifespan is determined by a pool of ovarian primordial follicles that are generated early in life. <jats:bold> Yu <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6165" page="1518" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1244587">1518</jats:related-article> ) found that in mice, the ubiquitin E3 ligase complex CRL4 is essential for oocyte survival within primordial follicles and for development after fertilization. CRL4 binds to and activates an adaptor protein that mediates ubiquitination, but if any component is deleted, the genes required for oocyte maintenance and early embryo development are silenced and the female mice become infertile. </jats:p>

<jats:title>G Structures</jats:title> <jats:p> G protein–coupled receptors (GPCRs) are eukaryotic membrane proteins that have a central role in cellular communication and have become key drug targets. To overcome the difficulties of growing GPCRs crystals, <jats:bold> Liu <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6165" page="1521" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1244142">1521</jats:related-article> ) used an x-ray free-electron laser to determine a high-resolution structure of the serotonin receptor from microcrystals. </jats:p>

<jats:title>More from mTOR</jats:title> <jats:p> Leigh syndrome is a rare, untreatable, inherited neurodegenerative disease in children that is caused by functional disruption of mitochondria, the cell's energy-producing organelles. <jats:bold> Johnson <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6165" page="1524" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1244360">1524</jats:related-article> , published online 14 November; see Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6165" page="1453" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1248449">Vafai and Mootha</jats:related-article> </jats:bold> ) show that rapamycin, a drug used clinically as an immunosuppressant and for treatment of certain cancers, delayed the onset and progression of neurological symptoms in a mouse model of Leigh syndrome and significantly extended survival of the animals. Rapamycin inhibits the so-called “mTOR” signaling pathway, which is currently under intense study because it plays a contributory role in many common diseases. </jats:p>

<jats:p>Standards of health care are changing rapidly across the globe and probably nowhere more quickly than in China. As treatments improve, survival to old age becomes more common, bringing about a shift from diseases of youth to diseases of old age, including a spectrum of neurodegenerative diseases such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis, and Huntington's. For this reason, there is some urgency among researchers to gain a better understanding of the etiology and biological basis of these disorders in order to affect preventative measures or even possible cures as well as find ways to improve the quality of life for current and future sufferers. This booklet looks at the current state of neurodegenerative research in China, outlining recent progress in the field and future prospects.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Standards of health care are changing rapidly across the globe and probably nowhere more quickly than in China. As treatments improve, survival to old age becomes more common, bringing about a shift from diseases of youth to diseases of old age, including a spectrum of neurodegenerative diseases such as Parkinson's, Alzheimer's, amyotrophic lateral sclerosis, and Huntington's. For this reason, there is some urgency among researchers to gain a better understanding of the etiology and biological basis of these disorders in order to affect preventative measures or even possible cures as well as find ways to improve the quality of life for current and future sufferers. This booklet looks at the current state of neurodegenerative research in China, outlining recent progress in the field and future prospects.</jats:p>

<jats:p>Listen to a special show on this year’s breakthrough, runners up, and the top stories from our daily news site.</jats:p>

<jats:title>Understanding Glycosylation</jats:title> <jats:p> Glycosylation—the covalent addition of carbohydrates to proteins—is central to many biological processes. Recent advances in understanding the roles of glycans—for example, in protein folding and immune regulation—have revealed that glycans are also involved in many disease conditions, from cancer to microbial infection. <jats:bold> Dalziel <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1235681">10.1126/science.1235681</jats:related-article> ) review the current knowledge of glycans in pathogen invasion, cancer, autoimmunity, and congenital diseases. </jats:p>