Catálogo de publicaciones - revistas

<jats:p> Applying tools from optogenetics with ideas from regenerative medicine may herald a new era of translational optogenetics. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="94" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1248523"> Bryson <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p> The fleeting stability of the cyanoformate ion formed from CO <jats:sub>2</jats:sub> and cyanide has implications for plant enzymology and CO <jats:sub>2</jats:sub> sequestration. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="75" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1250808"> Murphy <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p>Fences must be used with care in biodiversity conservation to avoid unintended consequences.</jats:p>

<jats:p> A pair of neurons in the CNS of flies controls and coordinates their ability to walk backward. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="97" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1249964"> Bidaye <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p>Future HIV vaccine research should consider the balance between responses that favor protection and those that lead to susceptibility to infection.</jats:p>

<jats:p> Mid-ocean ridge volcanoes sample a mantle that varies in temperature and composition. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="80" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1249466"> Dalton <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p> Paleoclimate data point to a warm tropical ocean with a clear east-west temperature gradient during the warm climates of the Pliocene and Miocene. <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="84" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1246172"> Zhang <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:title>Designer Chromosome</jats:title> <jats:p> One of the ultimate aims of synthetic biology is to build designer organisms from the ground up. Rapid advances in DNA synthesis has allowed the assembly of complete bacterial genomes. Eukaryotic organisms, with their generally much larger and more complex genomes, present an additional challenge to synthetic biologists. <jats:bold> Annaluru <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="55" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1249252">55</jats:related-article> , published online 27 March) designed a synthetic eukaryotic chromosome based on yeast chromosome III. The designer chromosome, shorn of destabilizing transfer RNA genes and transposons, is ∼14% smaller than its wild-type template and is fully functional with every gene tagged for easy removal. </jats:p>

<jats:title>Completing the Set</jats:title> <jats:p> G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate diverse signaling pathways. Significant insight into GPCR function has come from structures of three of four classes of GPCRs—A, B, and Frizzled. <jats:bold> Wu <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="58" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1249489">58</jats:related-article> , published online 6 March) complete the picture by reporting the structure of metabotropic glutamate receptor 1, a class C GPCR. The structure shows differences in the seven-transmembrane (7TM) domain between class C and other classes; however, the overall fold is preserved. Class C GPCRs are known to form dimers through their extracellular domains; however, the structure suggests additional interactions between the 7TM domains mediated by cholesterol. </jats:p>

<jats:title>Engineering Larger DNA Structures</jats:title> <jats:p> Several approaches now exist for the self-assembly of DNA into nanostructures. For example, three-arm DNA tripods can be assembled into larger wireframe polyhedra, but for the most complicated shapes, assembly yields can be low, apparently because the flexibility of smaller tripods allows for misassembly. <jats:bold> Iinuma <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6179" page="65" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1250944">65</jats:related-article> , published online 13 March) now show that larger, stiffer tripods that have controlled arm lengths and interarm angles can be designed to form a wide variety of open wireframe polyhedra—including tetrahedra, cubes, and hexagonal prisms, with edges 100 nanometers in length. </jats:p>