Catálogo de publicaciones - revistas

<jats:title>Immunogenetic Variation</jats:title> <jats:p> Many genetic variants have been implicated in disease but their effects in function across tissues and cell-types remain to be resolved. <jats:bold> Raj <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6183" page="519" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1249547">519</jats:related-article> ) present an analysis of expression quantative trait loci (eQTL) measuring messenger RNA levels and examined correlations between genotypes and gene expression in purified monocytes and T cells in healthy individuals of European, African, and Asian descent. Most, but not all, of the eQTLs and their effects on expression were shared between the populations, as well as a substantial proportion between the cell types. Links were found with disease-associated variants and loci that previous genome-wide analyses have implicated in neurodegenerative and autoimmune diseases. </jats:p>

<jats:title>Methylating the Family Tree</jats:title> <jats:p> DNA sequences show a high level of similarities between humans and ancient hominids but the degree to which there are differences between methylated regions in their genomes that may explain phenotypic differences is unclear. <jats:bold> Gokhman <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6183" page="523" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1250368">523</jats:related-article> , published online 17 April) demonstrate that naturally degraded methylated cytosines in ancient DNA are converted to thymines and can be used to reconstruct ancient methylomes. The results suggest differences in methylation in bone tissues between modern humans and ancient hominids in a set of genes important for limb development. </jats:p>

<jats:title>Remodelin Nuclear Defects</jats:title> <jats:p> Deregulation of A-type lamin proteins leads to disorganization of chromatin structure and misshapen nuclei, which are believed to underlie the pathologies of various human diseases, including the premature aging disorder Hutchinson Gilford progeria syndrome (HGPS) and various cancers. <jats:bold> Larrieu <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6183" page="527" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1252651">527</jats:related-article> ) developed a small molecule, Remodelin, that not only improved nuclear shape defects of human lamin A/C–depleted cells, HGPS cells, and aged normal cells, but also decreased the levels of a DNA damage marker and improved global cellular fitness. </jats:p>

<jats:title>Watching Brain Molecules</jats:title> <jats:p> Functional neuroimaging using magnetic resonance imaging (MRI) molecular sensors would be useful for mechanistic analysis of neural systems. <jats:bold> Lee <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6183" page="533" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1249380">533</jats:related-article> ) applied MRI-detectable sensors to measure molecular aspects of brain function in conjunction with noninvasive imaging. The molecular sensor revealed a quantitative spatiotemporal map of dopamine release in the ventral striatum, a brain area involved in processing rewards. </jats:p>

<jats:p>The diversity of options for today's microscopes—objectives and cameras, advanced stages and software, sources of illumination, and more—challenge even the experts when designing a new system. The process gets even more complex when faced with constraints, such as a budget or a specific set of necessary applications. Consequently, life scientists need to know where to spend and when to save. The experts interviewed here provide some pointers and give us insight into some of the newest components in the fast-changing field of microscopy.</jats:p>

<jats:p>On this week's show: climate change and crop optimization and a roundup of stories from our daily news site.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> Nuclear magnetic resonance data show how molecular chaperones recognize and prevent aggregation and misfolding of unfolded proteins. <jats:named-content content-type="related-content"> [Also see Perspective by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6184" page="590" related-article-type="in-this-issue" vol="344" xlink:href="10.1126/science.1254064">Gamerdinger and Deuerling</jats:related-article> ] </jats:named-content> </jats:p>

<jats:title>Hearing Aid</jats:title> <jats:p> Many millions of people across the globe are subject to hearing loss. <jats:bold>Géléoc and Holt</jats:bold> ( <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1241062">10.1126/science.1241062</jats:related-article> ) review recent developments in potential therapeutic strategies to restore inner-ear function in patients with acquired or genetic forms of deafness. While challenges remain, fundamental research in molecular, gene, and stem-cell therapies has enabled progress toward developing alternatives to conventional, sound amplification–based prostheses. </jats:p>