Catálogo de publicaciones - revistas

<jats:title>Tricky star plays sleight-of-light</jats:title> <jats:p> Two signatures in starlight thought to be written by extrasolar planets may turn out to be forgeries. Astronomers often attribute periodic shifts in a star's apparent motion toward and away from us to the tug of orbiting planets. Robertson <jats:italic>et al.</jats:italic> studied archival spectra of the star Gliese 581 to assess another potential cause: magnetic activity on the star's surface. The signals once attributed to two planet candidates instead resulted from the combined effect of starspots and stellar rotation. Planet hunters be warned—correct for stellar activity in your data analyses. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="440" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1253253">440</jats:related-article> </jats:p>

<jats:title>Climates conspire together to make big changes</jats:title> <jats:p>The regional climates of the North Pacific and North Atlantic fluttered between synchrony and asynchrony during the last deglaciation, with correspondingly more and less intense effects on the rest of the world, researchers have found. The climate system can be highly nonlinear, meaning that small changes in one part can lead to much larger changes elsewhere. This type of behavior is especially evident during transitions from glacial to interglacial conditions, when climate is affected by a wide variety of time-varying influences and is relatively unstable. Praetorius and Mix present a record of North Pacific climate over the past 18,000 years. When the climates of the more local high-latitude Pacific and Atlantic sectors varied in parallel, large, abrupt climate fluctuations occurred on a more global scale.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="444" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1252000">444</jats:related-article> </jats:p>

<jats:title>Wastewater disposal linked to earthquakes</jats:title> <jats:p> The number of earthquakes is increasing in regions with active unconventional oil and gas wells, where water pumped at high pressure breaks open rock containing natural gas, leaving behind wastewater in need of disposing. Keranen <jats:italic>et al.</jats:italic> show that the steep rise in earthquakes in Oklahoma, USA, is likely caused by fluid migration from wastewater disposal wells. Twenty percent of the earthquakes in the central United States could be attributed to just four of the wells. Injected fluids in high-volume wells triggered earthquakes over 30 km away. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="448" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1255802">448</jats:related-article> </jats:p>

<jats:title>Feathers, not just for the birds?</jats:title> <jats:p> Theropod dinosaurs, thought to be the direct ancestors of birds, sported birdlike feathers. But were they the only feathery dino group? Godefroit <jats:italic>et al.</jats:italic> describe an early neornithischian dinosaur with both early feathers and scales. This seemingly feathery nontheropod dinosaur shows that feathers were not unique to the ancestors of birds and may even have been quite widespread. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="451" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1253351">451</jats:related-article> </jats:p>

<jats:title>Problems making proteins kills nerve cells</jats:title> <jats:p> Neurodegeneration is associated with a variety of different diseases, but its cellular roots are often obscure. Ishimura <jats:italic>et al.</jats:italic> find that mutant mice whose brain cells start to die rapidly soon after birth have lost the function of two vital cellular components (see the Perspective by Darnell). The first is a protein that releases stalled ribosomes stuck on messenger RNA (mRNA); the second is a transfer RNA (tRNA), which reads the code for arginine in the mRNA. This tRNA is expressed predominantly in the central nervous system. The lack of the tRNA leads to increased ribosomal stalling at arginine codons, which, when left uncorrected, blocks protein synthesis and proves fatal. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="455" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1249749">455</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="378" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1257193">378</jats:related-article> </jats:p>

<jats:title>A membrane-activated switch to bind clathrin</jats:title> <jats:p> Clathrin-mediated endocytosis—the process by which cells take up nutrients and signals within clathrin-coated vesicles—is very well understood. Kelly <jats:italic>et al.</jats:italic> reveal an unanticipated layer of regulation in this process. The proteins AP2 and clathrin are the major constituents of endocytic clathrin-coated vesicles. AP2 and clathrin stick together through a clathrin-binding motif in AP2. The authors now show that AP2's clathrin-binding motif is normally buried within the core of the AP2 protein. AP2 only ejects its clathrin-binding motif and recruits clathrin if it is associated with the correct cell membrane and an endocytic cargo. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="459" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1254836">459</jats:related-article> </jats:p>

<jats:title>Making tropomodulin find the right point</jats:title> <jats:p> Actin filaments are a key component of the cell's cytoskeleton. Actin filaments have a characteristic polarized architecture with a so-called barbed end and a pointed end—so described because of how the filaments look under the electron microscope when they are coated with tropomyosin. Rao <jats:italic>et al.</jats:italic> describe crystal structures of a protein that uniquely binds and caps the pointed end of actin filaments. This protein, tropomodulin, binds to several actin subunits and to a couple of tropomyosin molecules, which generates a high-affinity specific cap to the filaments by combining low-affinity interactions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6195" page="463" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1256159">463</jats:related-article> </jats:p>

<jats:p>Some scientists keep experimental records on sticky notes. Some groups maintain ordering information in the head of a single technician. But for researchers looking for more stable, searchable, and sharable records, digital options such as electronic laboratory notebooks (ELNs) and laboratory information management systems (LIMS) are readily available. Scientists can start with a simple online notebook or choose a complete lab management package to track the entire lifecycle of their projects.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Western blotting has been a standard protein analytical technique for over 30 years and is used in practically every life sciences lab by thousands of scientists worldwide. Western blotting data appears in thousands of published papers annually but, despite its popularity, the method remains as much of a skilled art as a science, and it is often a significant challenge to produce reproducible and reliable results. In this webinar we invite three experts to give us their hints and tips of how to get the best possible Western blot data using current techniques as well as take a glimpse into the future of how technological advances could bring the needed standardization to Western blotting.</jats:p>