Catálogo de publicaciones - revistas

<jats:title>A dual-action RNA switch for expression</jats:title> <jats:p> Riboswitches are short segments of RNA that bind small molecules and switch between two different conformations, thereby regulating gene expression (see the Perspective by Chen and Gottesman). DebRoy <jats:italic>et al.</jats:italic> and Mellin <jats:italic>et al.</jats:italic> find a new class of riboswitches—in two different species of bacteria—that are both part of and regulate the production of a noncoding RNA. Each riboswitch ensures that a particular metabolic pathway is only activated in the presence of an essential small-molecule cofactor. In the absence of the cofactor, the full-length non-coding RNA is made and binds a regulator protein, preventing the regulator protein from inappropriately activating the metabolic pathway. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6199" page="937" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1255091">937</jats:related-article> and p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6199" page="940" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1255083">940</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6199" page="876" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1258494">876</jats:related-article> </jats:p>

<jats:title>Opening and closing blood enhancers</jats:title> <jats:p> As cells develop and differentiate into different types, the shape and accessibility of their DNA can change. Lara-Astiaso <jats:italic>et al.</jats:italic> studied this phenomenon in blood. They developed a technique that examines a relatively small number of cells to identify the changes that affect DNA during blood development. They found that the DNA of noncoding regions, called enhancers, is set in an open position when cells are undifferentiated and able to take on a variety of roles and gradually closes as cells mature into their final forms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6199" page="943" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1256271">943</jats:related-article> </jats:p>

<jats:title>The genomic origins of rape oilseed</jats:title> <jats:p> Many domesticated plants arose through the meeting of multiple genomes through hybridization and genome doubling, known as polyploidy. Chalhoub <jats:italic>et al.</jats:italic> sequenced the polyploid genome of <jats:italic>Brassica napus</jats:italic> , which originated from a recent combination of two distinct genomes approximately 7500 years ago and gave rise to the crops of rape oilseed (canola), kale, and rutabaga. <jats:italic>B. napus</jats:italic> has undergone multiple events affecting differently sized genetic regions where a gene from one progenitor species has been converted to the copy from a second progenitor species. Some of these gene conversion events appear to have been selected by humans as part of the process of domestication and crop improvement. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6199" page="950" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1253435">950</jats:related-article> </jats:p>

<jats:p>As the messenger of genetic information, RNA plays an important regulatory role in cell and tissue development as well as during disease progression. Understanding the best ways to work with RNA and the various RNA detection methods can help scientists advance our understanding of gene expression patterns and elucidate the roles of different genomic elements in cellular function and dysfunction. A variety of RNA detection methods–including Northern blotting, in situ hybridization, and reverse transcription polymerase chain reaction–are already available; however, each comes with its own advantages and limitations in signal sensitivity, specificity, and stability. Additionally, most often detection is carried out on lysed cell samples, so a significant amount of information is lost. This webinar will bring together two experts who will share their knowledge and expertise in a variety of RNA detection methodologies, including one that utilizes live cells.</jats:p>

<jats:p>On this week's show: Reverse engineering internet censorship in China and a news roundup.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Now more than ever, experts say, postdoctoral fellows need to cultivate a broad base of beyond-the-bench skills and capitalize on transferring them to the next stage of their career to be as competitive as possible. In today's competitive job market, it is vitally important for postdocs to accumulate skill sets on their CVs right alongside their publications–whether their next career move is research-based or not. Postdocs who repurpose their lab leadership and project management skills into star candidate qualities have an advantage when looking to step into their next position.</jats:p>

<jats:title>Arctic genetics comes in from the cold</jats:title><jats:p>Despite a well-characterized archaeological record, the genetics of the people who inhabit the Arctic have been unexplored. Raghavan<jats:italic>et al.</jats:italic>sequenced ancient and modern genomes of individuals from the North American Arctic (see the Perspective by Park). Analyses of these genomes indicate that the Arctic was colonized 6000 years ago by a migration separate from the one that gave rise to other Native American populations. Furthermore, the original paleo-inhabitants of the Arctic appear to have been completely replaced approximately 700 years ago.</jats:p><jats:p><jats:italic>Science</jats:italic>, this issue<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1255832">10.1126/science.1255832</jats:related-article>; see also p.<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6200" page="1004" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1258607">1004</jats:related-article></jats:p>