Catálogo de publicaciones - revistas

<jats:p>Beyond their contribution to basic metabolism, the major cellular organelles, in particular mitochondria, can determine whether cells respond to stress in an adaptive or suicidal manner. Thus, mitochondria can continuously adapt their shape to changing bioenergetic demands as they are subjected to quality control by autophagy, or they can undergo a lethal permeabilization process that initiates apoptosis. Along similar lines, multiple proteins involved in metabolic circuitries, including oxidative phosphorylation and transport of metabolites across membranes, may participate in the regulated or catastrophic dismantling of organelles. Many factors that were initially characterized as cell death regulators are now known to physically or functionally interact with metabolic enzymes. Thus, several metabolic cues regulate the propensity of cells to activate self-destructive programs, in part by acting on nutrient sensors. This suggests the existence of “metabolic checkpoints” that dictate cell fate in response to metabolic fluctuations. Here, we discuss recent insights into the intersection between metabolism and cell death regulation that have major implications for the comprehension and manipulation of unwarranted cell loss.</jats:p>

<jats:p> On 3 July 1880, “a weekly journal of scientific progress” published its first research articles under the banner <jats:italic>Science</jats:italic> . From that original print medium, the inaugural set of papers has been reprinted, photocopied, posted online, converted to PDF, and even etched in glass blocks to serve as special gifts. Being part of the vanguard is indeed a privilege, and opportunities to be one of the first are rare. For that reason, I proudly announce that <jats:italic>Science Advances</jats:italic> , a new open-access journal for all of the sciences, officially joins the <jats:italic>Science</jats:italic> family of journals ( <jats:italic>Science, Science Translational Medicine</jats:italic> , and <jats:italic>Science Signaling</jats:italic> ) and is now accepting submissions (go to <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.scienceadvances.org">www.scienceadvances.org</jats:ext-link> ). In February 2015, the inaugural papers will be released, heralding the start of something big in scope, reach, and influence. </jats:p>

<jats:p>The war on environmental degradation has a powerful new ally: Pope Francis. Prompted by a Joint Workshop of the Pontifical Academy of Sciences and the Pontifical Academy of Social Sciences on sustainability that was convened in May 2014, the Vatican has articulated some of its strongest environmental statements to date, calling for all of us to take personal responsibility and redirect our relationship with nature to ensure the future habitability and sustainability of this planet (see the Perspective on p. 1457). The problems that motivate the Vatican are no different from those that concern the scientific community: depletion of nonrenewable resources, loss of ecosystem services, and risks from changing climate. But what the Vatican contributes is the rationale for taking action: because it is our moral responsibility to bequeath a habitable planet to future generations.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>By tracking meteorite falls, camera and radar networks help searchers find precious fragments.</jats:p>

<jats:p>With more sensitive genetic tests, researchers are hunting the roots of disease in the human “mosaic.”</jats:p>

<jats:p>Science communicators and some highly cited researchers, but few women, make top 50 most followed list.</jats:p>

<jats:p>Scaling up production of Ebola vaccines and treatments will take many months.</jats:p>