Catálogo de publicaciones - revistas

<jats:p>The CRISPR-Cas9 system is revolutionizing genomic engineering and equipping scientists with the ability to precisely modify the DNA of essentially any organism. Just how powerful is this technique? The ability for precision genome engineering comes with the potential to enhance food production, medicinal discoveries, and energy solutions, to name a few. In this booklet, we invite you to explore a selection of Science articles that highlight how this technique has grown into one of the most powerful genomic engineering tools to date.</jats:p> <jats:p> This booklet brought to you by the <jats:italic>Science</jats:italic> /AAAS Custom Publishing Office. </jats:p> <jats:p>DOI: 10.1126/science.opms.sb0002</jats:p>

<jats:p>Growing human cells in culture for research is one thing, but the isolation and culture of high-quality cells that will be re-injected back into the donor is quite another. Manipulation and expansion of cells in a clinical setting carries its own unique requirements and complications. Growth and survival needs to be optimized and quality control is paramount. Often only a single opportunity for successful treatment is possible, so chances of success need to be maximized in all respects, including high-yield isolation of good quality cells from patients, cell culture conditions, cell characterization, and reperfusion back into patients. During this webinar, we will broadly examine the process of immunotherapy as well as examine in more detail some of the most critical steps along the pathway to generating a therapeutic dose of modified cells.</jats:p>

<jats:p>The CRISPR-Cas9 system is revolutionizing genomic engineering and equipping scientists with the ability to precisely modify the DNA of essentially any organism. Just how powerful is this technique? The ability for precision genome engineering comes with the potential to enhance food production, medicinal discoveries, and energy solutions, to name a few. In this booklet, we invite you to explore a selection of Science articles that highlight how this technique has grown into one of the most powerful genomic engineering tools to date.</jats:p> <jats:p> This booklet brought to you by the <jats:italic>Science</jats:italic> /AAAS Custom Publishing Office. </jats:p> <jats:p>DOI: 10.1126/science.opms.sb0002</jats:p>

<jats:title>Mapping human drug targets in the cell</jats:title> <jats:p> To understand both the beneficial and the side effects of a drug, one would need to know its full binding profile to all cellular proteins. Savitski <jats:italic>et al.</jats:italic> take significant steps toward meeting this daunting challenge. They monitored the unfolding or “melting” of over 7000 human proteins and measured how small-molecule binding changes individual melting profiles. As a proof of principle, over 50 targets were identified for an inhibitor known to bind a broad spectrum of kinases. Two cancer drugs, vemurafib and Alectinib, are known to have a side effect of photosensitivity. The thermal profiling approach identified drug-protein interactions responsible for these side effects. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1255784">10.1126/science.1255784</jats:related-article> </jats:p>

<jats:title>Controlling stem cells and their niches</jats:title> <jats:p> Adult organs such as the intestines and skin continually renew themselves every few days or weeks. In several mammalian tissues, this renewal relies on Wnt signaling. Clevers <jats:italic>et al.</jats:italic> review this crucial role in stem cell self renewal. Wnt plays a pivotal role in tissue regeneration even in the earliest animals. Wnt proteins function mainly as short-range signals between adjacent cells. The short-range, spatially-constrained nature of Wnt signals underpins mammalian stem cell niche architecture and tissue self-organization. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1248012">10.1126/science.1248012</jats:related-article> </jats:p>

<jats:title>Biological sensing using nanoparticles</jats:title> <jats:p> Colloidal fluorescent and plasmonic nanoparticles yield intense responses to incident light, making them useful as sensors or probes for sensitive detection in solution. Howes <jats:italic>et al.</jats:italic> review the potential uses of nanoparticle biosensors in research and diagnostics. A range of methods allow for the chemical modification of the particle surfaces so that they can be tuned for specific analytes and give optical signals for a range of biological conditions of interest. Signals can be detected in complex media or in vivo making the particles of interest for both laboratory research and in clinical settings. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1247390">10.1126/science.1247390</jats:related-article> </jats:p>

<jats:p>Nine billion people are expected to inhabit Planet Earth by 2050. Without agricultural research, there is little hope of sustaining this population surge, given that arable land and water supplies are fixed commodities. Yet for decades the agricultural sector has suffered from neglect. If we want to combat new strains of pests that destroy crops, find new crop varieties enriched in nutritional value, improve yields, develop resistance to disease and drought, and provide environmentally sensitive cultivation practices, then agricultural research must be a priority. Why isn't it?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Repeated cases among health care workers are a puzzle, but more staff and better training may lower risks.</jats:p>