Catálogo de publicaciones - revistas

<jats:title>Predicting defects in RNA splicing</jats:title> <jats:p> Most eukaryotic messenger RNAs (mRNAs) are spliced to remove introns. Splicing generates uninterrupted open reading frames that can be translated into proteins. Splicing is often highly regulated, generating alternative spliced forms that code for variant proteins in different tissues. RNA-binding proteins that bind specific sequences in the mRNA regulate splicing. Xiong <jats:italic>et al.</jats:italic> develop a computational model that predicts splicing regulation for any mRNA sequence (see the Perspective by Guigó and Valcárcel). They use this to analyze more than half a million mRNA splicing sequence variants in the human genome. They are able to identify thousands of known disease-causing mutations, as well as many new disease candidates, including 17 new autism-linked genes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1254806">10.1126/science.1254806</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6218" page="124" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa4864">124</jats:related-article> </jats:p>

<jats:p> Last month, the European Commission (EC) Scientific Committees issued a draft opinion on whether existing risk assessment methods are adequate for synthetic biology. This opinion, which was written by a Working Group of 20 experts from Europe and the United States, <jats:xref ref-type="fn">*</jats:xref> could have a substantial impact on shaping European and global synthetic biology policy for years to come. It is open for public comment through 3 February 2015. <jats:xref ref-type="fn">†</jats:xref> </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Europe's Laser Mégajoule project blazes its own trail toward nuclear ignition.</jats:p>

<jats:p>New guidelines lower the barrier for patenting products derived from nature, quelling some biotech fears.</jats:p>

<jats:p>Mimicking real tissue, novel materials lead to flexible electrode implants that help paralyzed animals walk again.</jats:p>