Catálogo de publicaciones - revistas

<jats:title>Getting a grip</jats:title> <jats:p> The evolution of the hand—particularly the opposable thumb—was key to the success of early humans. Without a precise grip, involving forceful opposition of thumb with fingers, tool technology could not have emerged. Skinner <jats:italic>et al.</jats:italic> analyzed the internal bone structure of Pliocene <jats:italic>Australopithecus</jats:italic> hands, dated at 3.2 million years old. Internal bone structure reveals the patterns and directions of forces operating on the hand, providing clues to the kinds of activities performed. Modern human-like hand postures consistent with the habitual use of tools appeared about half a million years earlier than the first archaeological evidence of stone tools. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6220" page="395" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1261735">395</jats:related-article> </jats:p>

<jats:title>For T cells, variety is the spice of life</jats:title> <jats:p> CD4 <jats:sup>+</jats:sup> helper T cells come in a variety of flavors. This allows them to respond in a manner that is tailored to the pathogen they encounter. Becattini <jats:italic>et al.</jats:italic> wondered whether multiple “flavors” of human CD4 <jats:sup>+</jats:sup> T cells respond to specific stimuli or if just one flavor dominates. To find out, they stimulated human memory CD4 <jats:sup>+</jats:sup> T cells with a fungus, a bacteria, or a vaccine antigen. Multiple helper cell subsets participated in each response. T cell receptor sequencing revealed that in some cases, T cells with the same specificity acquired different helper cell fates. Thus, there is more heterogeneity in human T cell responses than previously appreciated. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6220" page="400" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1260668">400</jats:related-article> </jats:p>