Catálogo de publicaciones - revistas

<jats:title>Assessing the value of undergraduate research</jats:title> <jats:p> Undergraduate research experiences often engender enthusiasm in the students involved, but how useful are they in terms of enhancing student learning? Linn <jats:italic>et al.</jats:italic> review studies that focus on the effectiveness of undergraduate research programs. Undergraduate research experiences in a class were distinguished from those involving individualized participation in a research program. Mentoring emerges as both an important component of a successful experience and a target for improvement. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1261757">10.1126/science.1261757</jats:related-article> </jats:p>

<jats:title>Single-cell expression analysis on a large scale</jats:title> <jats:p> To understand why cells differ from each other, we need to understand which genes are transcribed at a single-cell level. Several methods measure messenger RNA (mRNA) expression in single cells, but most are limited to relatively low numbers of cells or genes. Fan <jats:italic>et al.</jats:italic> labeled each mRNA molecule in a cell with both a cellular barcode and a molecular barcode. Further analysis did not then require single-cell technologies. Instead, the labeled mRNA from all cells was pooled, amplified, and sequenced, and the gene expression profile of individual cells was reconstructed based on the barcodes. The technique successfully revealed heterogeneity across several thousand blood cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1258367">10.1126/science.1258367</jats:related-article> </jats:p>

<jats:p>s I retire from the office of chief executive of the American Association for the Advancement of Science (AAAS) and pass the baton to my very capable successor, physicist and former U.S. congressman Rush Holt, I have been reflecting on changes over the past decades both within the scientific enterprise and in its relationship with the rest of society. Many trends are cause for celebration, but others require remedial attention. On the positive side, new technologies have enabled new and very important scientific questions to be confronted, and a rise in collaborative, multidisciplinary science has fueled a remarkable pace of discovery. Science is also becoming more global in character as more countries invest in science and technology and fortify their infrastructures and science capacities. Science has never been more productive. And yet, the overall climate for science is more difficult than I have ever seen in my scientific career. This stunning state of contradiction indicates that there has never been a greater need, or a greater opportunity, for an international organization such as AAAS, whose mission is to advance science and serve society.</jats:p>