Catálogo de publicaciones - revistas

<jats:title>Reversing cocaine-evoked behavior in mice</jats:title> <jats:p> Therapeutic optogenetic protocols are highly effective at reversing symptoms in animal models of neuropsychiatric disease. However, translating these protocols into the clinic is challenging because we have not yet made the technical leap required to perform effective optogenetic stimulation in primates. Creed <jats:italic>et al.</jats:italic> tested whether it would be possible to circumvent these challenges by avoiding the problem altogether. They adjusted an existing therapeutic approach—deep brain stimulation—to mimic an effective optogenetic stimulation protocol to treat a mouse model of cocaine addiction. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6222" page="659" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1260776">659</jats:related-article> </jats:p>

<jats:title>How genetics affect phenotypic variation</jats:title> <jats:p> How an individual looks depends on their genes, genetic variation, and interactions with the environment. However, the path from genotype to phenotype remains murky. Battle <jats:italic>et al.</jats:italic> examine how an individual's genetic variation affects expression of RNA, ribosome occupancy, and protein levels. They find that RNA expression and ribosome occupancy are generally correlated. However, in contrast, protein levels appear not to depend on RNA levels or ribosome occupancy. Protein levels are thus regulated by posttranscriptional mechanisms. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6222" page="664" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1260793">664</jats:related-article> </jats:p>

<jats:title>Bacterial infection breaks the lymph node barrier</jats:title> <jats:p> During infections, lymph nodes are command central. Fragments from invading pathogens enter lymph nodes through the lymph. There, specialized cells called subcapsular sinus (SCS) macrophages capture these antigens and use them to initiate humoral immunity. Despite being such important players, Gaya <jats:italic>et al.</jats:italic> report that in mice, infection throws these organized sentinels into disarray (see the Perspective by Buzsaki). Disrupting SCS macrophages had important consequences: Bacterially infected mice could not respond as efficiently to a subsequent viral infection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6222" page="667" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa1300">667</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6222" page="612" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa6505">612</jats:related-article> </jats:p>

<jats:title>Exploring the limits of protein sequence space</jats:title> <jats:p> Exploring the variability of individual functional proteins is complicated by the vast number of combinations of possible amino acid sequences. Podgornaia and Laub take on this challenge by analyzing four amino acids critical for the interaction between two signaling proteins in <jats:italic>Escherichia coli.</jats:italic> They build all the possible 160,000 variants of one of the two proteins and find that over 1650 are functional. Even though there can be very high variability in the composition of the interface between the two proteins, there are nonetheless strong context-dependent constraints for some amino acids, which suggests why many functional variants are not seen in nature. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6222" page="673" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.1257360">673</jats:related-article> </jats:p>

<jats:p>On this week's show: The brain's spatial maps, and a roundup of daily news stories.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> This webinar is the second in a series focusing on the cancer pathways that support tumor development, the emerging research in identifying and targeting these pathways, and innovations in the development of increasingly effective cancer therapy options. Recent advances in our understanding of cancer have revealed that the disease cannot be understood through simple analysis of genetic mutations within cancerous cells. Instead, tumors should be considered complex tissues in which the cancer cells communicate with the surrounding cellular microenvironment and evolve traits that promote their own survival. Here, we will explore how the tumor microenvironment promotes oncogenic progression, while protecting the tumor from therapeutic intervention. By better understanding the tumor microenvironment we can develop strategies and treatment options to neutralize its oncogenic influence and more effectively attack the tumor itself. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://webinar.sciencemag.org/webinar/archive/part-2-targeting-cancer-pathways">View the Webinar</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>