Catálogo de publicaciones - revistas

<jats:title>Innate immune receptor signaling, united</jats:title> <jats:p> Innate immune receptors such as RIG-I, cGAS, and Toll-like receptors bind microbial fragments and alert the immune system to an infection. Each receptor type signals through a different adapter protein. These signals activate the protein kinase TBK1 and the transcription factor IRF3, which tells cells to secrete interferon proteins (IFNs) important for host defense. Liu <jats:italic>et al.</jats:italic> now report a common signaling mechanism used by all three types of innate immune receptor-adaptor protein pairs to activate IRF3 and generate IFNs. This is important because cells must regulate their IFN production carefully to avoid inflammation and autoimmunity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaa2630">10.1126/science.aaa2630</jats:related-article> </jats:p>

<jats:p>Chemistry is the great enabler. For two centuries, it has played a key role in conquering diseases, solving energy problems, addressing environmental challenges, and providing discoveries that have spawned new industries. To meet the demands of the future, this mature science must expand into new frontiers, a move that will be facilitated if the public and policy-makers understand its pivotal role in every facet of life. Such support will not be forthcoming from those who associate chemistry with harm—intentional or not—to people and the biosphere. Addressing the disparity between those perceptions and the reality of chemistry's contributions to society will garner broader support for spurring innovations in the 21st century. How can chemistry ensure that it has this support?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Some worry the massive accelerator could produce nothing besides the Higgs boson.</jats:p>

<jats:p>Warming linked to urbanization prevents low clouds from forming, Los Angeles area study shows.</jats:p>

<jats:p>The Islamic State group strikes one valuable archaeological site after another, destroying priceless ruins and artifacts.</jats:p>

<jats:p>Ultrasound methods breach blood-brain barrier.</jats:p>

<jats:p>Novel variants of H7N9 and other strains are arising at alarming rate.</jats:p>

<jats:p>With health services devastated in the wake of Ebola, experts are bracing for a deadly measles outbreak in West Africa.</jats:p>