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Science
Resumen/Descripción – provisto por la editorial
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Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Something fishy about synthetic armor
M. S. Lavine
Palabras clave: Multidisciplinary.
Pp. 1433-1433
Weaning means more than no more milk
B. A. Purnell
Palabras clave: Multidisciplinary.
Pp. 1433-1433
The hazards of isolation
S. Vignieri
Palabras clave: Multidisciplinary.
Pp. 1433-1433
A CURE for promoting undergraduate research
M. McCartney
Palabras clave: Multidisciplinary.
Pp. 1433-1433
Ionic liquids can ring in carbon dioxide
J. Yeston
Palabras clave: Multidisciplinary.
Pp. 1433-1433
A CRISPR view of tumor metastasis
P. A. Kiberstis
Palabras clave: Multidisciplinary.
Pp. 1433-1433
Fatty acid trafficking in starvation
M. S. Magon
Palabras clave: Multidisciplinary.
Pp. 1433-1433
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Elizabeth T. Cirulli; Brittany N. Lasseigne; Slavé Petrovski; Peter C. Sapp; Patrick A. Dion; Claire S. Leblond; Julien Couthouis; Yi-Fan Lu; Quanli Wang; Brian J. Krueger; Zhong Ren; Jonathan Keebler; Yujun Han; Shawn E. Levy; Braden E. Boone; Jack R. Wimbish; Lindsay L. Waite; Angela L. Jones; John P. Carulli; Aaron G. Day-Williams; John F. Staropoli; Winnie W. Xin; Alessandra Chesi; Alya R. Raphael; Diane McKenna-Yasek; Janet Cady; J. M. B. Vianney de Jong; Kevin P. Kenna; Bradley N. Smith; Simon Topp; Jack Miller; Athina Gkazi; Ammar Al-Chalabi; Leonard H. van den Berg; Jan Veldink; Vincenzo Silani; Nicola Ticozzi; Christopher E. Shaw; Robert H. Baloh; Stanley Appel; Ericka Simpson; Clotilde Lagier-Tourenne; Stefan M. Pulst; Summer Gibson; John Q. Trojanowski; Lauren Elman; Leo McCluskey; Murray Grossman; Neil A. Shneider; Wendy K. Chung; John M. Ravits; Jonathan D. Glass; Katherine B. Sims; Vivianna M. Van Deerlin; Tom Maniatis; Sebastian D. Hayes; Alban Ordureau; Sharan Swarup; John Landers; Frank Baas; Andrew S. Allen; Richard S. Bedlack; J. Wade Harper; Aaron D. Gitler; Guy A. Rouleau; Robert Brown; Matthew B. Harms; Gregory M. Cooper; Tim Harris; Richard M. Myers; David B. Goldstein;
<jats:title>New players in Lou Gehrig's disease</jats:title> <jats:p> Amyotrophic lateral sclerosis (ALS), often referred to as “Lou Gehrig's disease,†is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Cirulli <jats:italic>et al.</jats:italic> sequenced the expressed genes of nearly 3000 ALS patients and compared them with those of more than 6000 controls (see the Perspective by Singleton and Traynor). They identified several proteins that were linked to disease in patients. One such protein, TBK1, is implicated in innate immunity and autophagy and may represent a therapeutic target. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6229" page="1436" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa3650">1436</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6229" page="1422" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa9838">1422</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1436-1441
The structure of the dynactin complex and its interaction with dynein
Linas Urnavicius; Kai Zhang; Aristides G. Diamant; Carina Motz; Max A. Schlager; Minmin Yu; Nisha A. Patel; Carol V. Robinson; Andrew P. Carter
<jats:title>Making a molecular motor fit for purpose</jats:title> <jats:p> Dynactin is an essential cofactor of the microtubule motor, cytoplasmic dynein. Dynactin contains 23 subunits built around a short filament of an actin-related protein (Arp1). How dynactin is assembled, how it functions with dynein, and why it is built around an actin-like filament is unclear. Urnavicius <jats:italic>et al.</jats:italic> combined cryo–electron microscopy structural studies and a crystal structure to determine the three-dimensional architecture of dynactin and how it interacts with dynein. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6229" page="1441" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa4080">1441</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1441-1446
Dynamic DNA devices and assemblies formed by shape-complementary, non–base pairing 3D components
Thomas Gerling; Klaus F. Wagenbauer; Andrea M. Neuner; Hendrik Dietz
<jats:title>Reconfigurable DNA structures</jats:title> <jats:p> DNA origami—nanostructures created by programming the assembly of single-stranded DNA through base pairing—can create intricate structures. However, such structures lack the flexible and reversible interactions more typical of biomolecular recognition. Gerling <jats:italic>et al.</jats:italic> created three-dimensional DNA nanostructures that assemble though nucleotide base-stacking interactions (see the Perspective by Shih). These structures cycled from open to closed states with changes in salt concentration or temperature. </jats:p> <jats:p> Science, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6229" page="1446" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa5372">1446</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6229" page="1417" related-article-type="in-this-issue" vol="347" xlink:href="10.1126/science.aaa9483">1417</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 1446-1452