Catálogo de publicaciones - revistas

<jats:title>Uncrossing covalently linked DNA strands</jats:title> <jats:p> DNA interstrand cross-links (ICLs) covalently link the two strands of the double helix. ICL mutations are difficult to repair, because the two DNA strands cannot be separated and so one strand cannot be used as a template to repair the other. Räschle <jats:italic>et al.</jats:italic> developed a mass spectrometry–based method to systematically analyze a time series of all the proteins recruited to repair ICLs in <jats:italic>Xenopus</jats:italic> egg extracts. They found many of the known factors required for ICL repair. They also found a number of new factors, two of which define a new repair pathway for ICL mutations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1253671">10.1126/science.1253671</jats:related-article> </jats:p>

<jats:p> Open records laws worldwide are critical to holding public institutions, including universities, accountable. Such laws protect against inappropriate influence on the scientific enterprise and promote public trust in the integrity of science and scientists. But the growing use of electronic communications by researchers makes these laws vulnerable to misuse. Conversations that used to occur in person and by other less-recordable means are now electronically written. Increasingly, activists across the political spectrum in several countries are requesting not only records of discussions about the strengths and weaknesses of work, but also preliminary paper drafts and private constructive criticisms from colleagues. These requests can attack and intimidate academics, threatening their reputations, chilling their speech, disrupting their research, discouraging them from tackling contentious topics, and ultimately confusing the public. <jats:xref ref-type="fn">*</jats:xref> So what level of disclosure is appropriate? How can public accountability be balanced with the privacy essential for scientific inquiry? </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Rupture in quiet region of crust suggests Himalayan threat was underestimated.</jats:p>

<jats:p>The country could soon be the epidemic's last holdout.</jats:p>