Catálogo de publicaciones - revistas

<jats:title>An optogenetic tool to silence neurons</jats:title> <jats:p> Potassium channels in the cell membrane open and close in response to molecular signals to alter the local membrane potential. Cosentino <jats:italic>et al.</jats:italic> linked a light-responsive module to the pore of a potassium channel to build a genetically encoded channel called BLINK1 that is closed in the dark and opens in response to low doses of blue light. Zebrafish embryos expressing BLINK1 in their neurons changed their behavior in response to blue light. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6235" page="707" related-article-type="in-this-issue" vol="348" xlink:href="10.1126/science.aaa2787">707</jats:related-article> </jats:p>

<jats:title>A way to dissect malaria's secrets</jats:title> <jats:p> Malaria has exerted a strong selective force on the human genome. However, efforts to identify host susceptibility factors have been hindered by the absence of a nucleus in red blood cells. Egan <jats:italic>et al.</jats:italic> developed an approach involving blood stem cells to discover host factors critical for <jats:italic>Plasmodium falciparum</jats:italic> infection of red blood cells. The authors identified an essential host receptor for parasite invasion that could provide a target for malaria therapeutics. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6235" page="711" related-article-type="in-this-issue" vol="348" xlink:href="10.1126/science.aaa3526">711</jats:related-article> </jats:p>

<jats:p> Genomic technologies present powerful tools with the potential to diagnose, treat, and elucidate the underpinnings of human disease. Technological advances have allowed researchers and clinicians to apply novel approaches and gain statistical power to delve more deeply and broadly into our genomes than ever before, enabling them to discover associations between genomic variants and disease phenotypes that were previously beyond our reach. In this webinar, we will explore how genomics is currently being applied to characterize rare disease and cancer, highlight recent advances in these respective areas, and look toward the future to predict what is needed to positively impact human health. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://webinar.sciencemag.org/webinar/archive/advancing-promise-genomic-medicine">View the Webinar</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>

<jats:p>On this week's show: Measles vaccination plays a major role in preventing childhood mortality from other infectious diseases, and a roundup of daily news stories.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>