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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

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doi: 10.1126/science.aaa0769

Systematic humanization of yeast genes reveals conserved functions and genetic modularity

Aashiq H. Kachroo; Jon M. Laurent; Christopher M. Yellman; Austin G. Meyer; Claus O. Wilke; Edward M. Marcotte

<jats:title>Staying the same across a billion years</jats:title> <jats:p> How far across evolution do families of genes retain their function? Yeast and humans are separated by roughly a billion years of evolutionary history, and yet genes from one can substitute for orthologous genes in the other. To study this effect systematically, Kachroo <jats:italic>et al.</jats:italic> replaced over 400 essential yeast genes with their human orthologs. Roughly half of the human genes could functionally replace their yeast counterparts. Genes being in the same pathway was as important as sequence or expression similarity in determining replaceability. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6237" page="921" related-article-type="in-this-issue" vol="348" xlink:href="10.1126/science.aaa0769">921</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 921-925

doi: 10.1126/science.348.6237.927-b

Science Podcast: 22 May Show

<jats:p>On this week's show: Testosterone and sex classification in elite sport, and a roundup of daily news stories.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 927-927

doi: 10.1126/science.348.6237.927-a

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 927-927

doi: 10.1126/science.348.6237.938