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Science

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

Georg Stary; Andrew Olive; Aleksandar F. Radovic-Moreno; David Gondek; David Alvarez; Pamela A. Basto; Mario Perro; Vladimir D. Vrbanac; Andrew M. Tager; Jinjun Shi; Jeremy A. Yethon; Omid C. Farokhzad; Robert Langer; Michael N. Starnbach; Ulrich H. von Andrian

<jats:title>The right combination for protection</jats:title> <jats:p> Despite its prevalence, no vaccine exists to protect against infection with the sexually transmitted bacterium <jats:italic>Chlamydia trachomatis</jats:italic> . Stary <jats:italic>et al.</jats:italic> now report on one potential vaccine candidate (see the Perspective by Brunham). Vaccinating with an ultraviolet light-inactivated <jats:italic>C. trachomatis</jats:italic> linked to adjuvant-containing charged nanoparticles protected female conventional and humanized mice against <jats:italic>C. trachomatis</jats:italic> infection. The vaccine conferred protection only when delivered through mucosal routes. Protection relied on targeting the bacteria to a particular population of immunogenic dendritic cells and inducing memory T cells that resided in the female genital tract. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaa8205">10.1126/science.aaa8205</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6241" page="1322" related-article-type="in-this-issue" vol="348" xlink:href="10.1126/science.aac6528">1322</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. No disponible

Composite membranes for filtering solvents

M. S. Lavine

Palabras clave: Multidisciplinary.

Pp. i-1327

Parks for science

Gary Machlis; Marcia McNutt

<jats:p>In March 1915, a historic conference of scientists, conservationists, and park leaders was held at the University of California, Berkeley. It helped create public support for national parks in the United States and the establishment in 1916 of the National Park Service (NPS). One hundred years later, a similar summit on the same Berkeley campus convened to examine the role of science in the next century of America's national parks. Science remains crucial to the future health of America's parks and protected areas worldwide. But national parks are also vital for science.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1291-1291

This week's section

<jats:p>A roundup of weekly science policy and related news.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1292-1294

The return of Philae

Eric Hand; Daniel Clery

<jats:p>Revived after hibernation, comet lander awaits orders.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1295-1295

Research chimps will soon be listed as ‘endangered’

David Grimm

<jats:p>Ruling could disrupt biomedical research.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1296-1296

Designer proteins produce potent HIV defense

Jon Cohen

<jats:p>AIDS vaccine developers mimic natural route to powerful immune responses.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1297-1297

Republicans split on climate, social science spending

Jeffrey Mervis

<jats:p>House calls for cuts, Senate favors status quo.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1298-1298

Pumped up to rumble

Julia Rosen

<jats:p>Massive studies of wastewater injection wells show fast pumping raises earthquake risk.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1299-1299

Last dance?

Marianne Lavelle

<jats:p>An urgent effort to save the West's iconic lesser prairie chicken could point the way to a truce in other endangered-species battles.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1300-1305