Catálogo de publicaciones - revistas

<jats:title>BMP mophogens direct growth and fate</jats:title> <jats:p>As shown in classic fate-mapping studies, tissues and organs arise from specific regions of the embryo. Work over the past few decades has identified molecular players directing this choreographed development. Bone morphogenetic proteins (BMPs) and their antagonists establish domains in developing embryos. Bier and De Robertis review historical events for key discoveries in this area. They go on to lay out the current understanding of how diffusible morphogens form gradients to subdivide germ layers into distinct territories and organize body axes, regulate growth, and maintain stem cell niches.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaa5838">10.1126/science.aaa5838</jats:related-article> </jats:p>

<jats:title>Making cardiomyocytes</jats:title> <jats:p> In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle lineages. However, the identity of a marker specific to cardiomyocyte formation has been elusive. Jain <jats:italic>et al.</jats:italic> now identify a specialized progenitor population that is committed exclusively to forming cardiomyocytes. They also identify the niche signals that promote lineage commitment and the mechanisms involved in making cardiomyocytes. The findings may help in the development of future cell-based regenerative therapeutics for heart disease. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaa6071">10.1126/science.aaa6071</jats:related-article> </jats:p>

<jats:p>The reproducibility problem in science is a familiar issue, not only within the scientific community, but with the general public as well. Recent developments in social psychology (such as fraudulent research by D. Stapel) and cell biology (the Amgen Inc. and Bayer AG reports on how rarely they could reproduce published results) have become widely known. Nearly every field is affected, from clinical trials and neuroimaging, to economics and computer science. Obvious solutions include more research on statistical and behavioral fixes for irreproducibility, activism for policy changes, and demanding more pre-registration and data sharing from grantees. Two Perspectives in this issue (pp. 1420 and 1422) describe how journals and academic institutions can foster a culture of reproducibility. Transparency is central to improving reproducibility, but it is expensive and time-consuming. What can be done to alleviate those obstacles?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>After recovering from Ebola, some patients are struggling with other health problems.</jats:p>

<jats:p>Chromosomal loops and domains help enhancers turn on genes.</jats:p>

<jats:p>Trick for pushing more bits through optical fibers could ease looming “capacity crunch.”</jats:p>