Catálogo de publicaciones - revistas

<jats:title>Steps in the right direction</jats:title> <jats:p> HIV-1 mutates rapidly, making it difficult to design a vaccine that will protect people against all of the virus' iterations. A potential successful vaccine design might protect by eliciting broadly neutralizing antibodies (bNAbs), which target specific regions on HIV-1's trimeric envelope glycoprotein (Env) (see the Perspective by Mascola). Jardine <jats:italic>et al.</jats:italic> used mice engineered to express germline-reverted heavy chains of a particular bNAb and immunized them with an Env-based immunogen designed to bind to precursors of that bNAb. Sanders <jats:italic>et al.</jats:italic> compared rabbits and monkeys immunized with Env trimers that adopt a nativelike conformation. In both cases, immunized animals produced antibodies that shared similarities with bNAbs. Boosting these animals with other immunogens may drive these antibodies to further mutate into the longsought bNAbs. Chen <jats:italic>et al.</jats:italic> report that retaining the cytoplasmic domain of Env proteins may be important to attract bNAbs. Removing the cytoplasmic domain may distract the immune response and instead generate antibodies that target epitopes on Env that would not lead to protection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6244" page="139" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac7800">139</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aac4223">10.1126/science.aac4223</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6244" page="156" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac5894">156</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6244" page="191" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aaa9804">191</jats:related-article> </jats:p>

<jats:title>Single-cell measurements map immunity</jats:title> <jats:p> Multiple characteristics of individual cells define cell types and their physiological states. Spitzer <jats:italic>et al.</jats:italic> quantitated the abundance of 39 different cell surface proteins or transcription factors on individual cells of the mouse immune system. They used these measurements to create a map that clustered similar individual cells into groups corresponding to cell type and function. Their extensible experimental platform will allow the inclusion of other data types and data from independent laboratories. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1259425">10.1126/science.1259425</jats:related-article> </jats:p>

<jats:title>Warming climate, melting ice, rising seas</jats:title> <jats:p> We know that the sea level will rise as climate warms. Nevertheless, accurate projections of how much sea-level rise will occur are difficult to make based solely on modern observations. Determining how ice sheets and sea level have varied in past warm periods can help us better understand how sensitive ice sheets are to higher temperatures. Dutton <jats:italic>et al.</jats:italic> review recent interdisciplinary progress in understanding this issue, based on data from four different warm intervals over the past 3 million years. Their synthesis provides a clear picture of the progress we have made and the hurdles that still exist. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaa4019">10.1126/science.aaa4019</jats:related-article> </jats:p>

<jats:p>Next week, the New Horizons spacecraft will reconnoiter Pluto and its system of moons on the ragged edge of our planetary system. It may then fly by icy bodies in the Kuiper Belt, more than a billion kilometers beyond Neptune's orbit. These will become the farthest worlds ever explored, ushering in a new era of discovery. Although information from previous planetary probes has helped scientists understand the origin of the inner rocky planets (Mercury, Venus, Earth, and Mars) and the gas giants (Jupiter, Saturn, Uranus, and Neptune), as well as their moons, this will be the first opportunity to undertake a close-up study of the dwarf planets that are so common beyond Neptune.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>