Catálogo de publicaciones - revistas

<jats:title>Steps in the right direction</jats:title> <jats:p> HIV-1 mutates rapidly, making it difficult to design a vaccine that will protect people against all of the virus' iterations. A potential successful vaccine design might protect by eliciting broadly neutralizing antibodies (bNAbs), which target specific regions on HIV-1's trimeric envelope glycoprotein (Env) (see the Perspective by Mascola). Jardine <jats:italic>et al.</jats:italic> used mice engineered to express germline-reverted heavy chains of a particular bNAb and immunized them with an Env-based immunogen designed to bind to precursors of that bNAb. Sanders <jats:italic>et al.</jats:italic> compared rabbits and monkeys immunized with Env trimers that adopt a nativelike conformation. In both cases, immunized animals produced antibodies that shared similarities with bNAbs. Boosting these animals with other immunogens may drive these antibodies to further mutate into the longsought bNAbs. Chen <jats:italic>et al.</jats:italic> report that retaining the cytoplasmic domain of Env proteins may be important to attract bNAbs. Removing the cytoplasmic domain may distract the immune response and instead generate antibodies that target epitopes on Env that would not lead to protection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6244" page="139" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac7800">139</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aac4223">10.1126/science.aac4223</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6244" page="156" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac5894">156</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6244" page="191" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aaa9804">191</jats:related-article> </jats:p>

<jats:title>Making jack jump efficiently</jats:title> <jats:p> In the future, soft-bodied robots may be able to squeeze into tight spaces or work in environments where they could be crushed. However, it is hard to ensure efficient power transmission in a soft-bodied device. One promising solution is to use explosions to drive the robot, using efficient weight-to-power energy sources. Using three-dimensional printing to fuse together multiple materials, Bartlett <jats:italic>et al.</jats:italic> built a combustion-powered robot. The robot has a rigid core that transitions to a soft exterior. They produced an efficient jumping robot in which the gradations in the hardness of the body materials also improved robustness. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6244" page="161" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aab0129">161</jats:related-article> </jats:p>