Catálogo de publicaciones - revistas

<jats:title>To defeat SIV, add a protein boost</jats:title> <jats:p> Despite 30 years of effort, no HIV-1 vaccine exists. Barouch <jats:italic>et al.</jats:italic> evaluated one promising strategy in rhesus macaques, a preclinical model commonly used to test potential HIV-1 vaccine candidates. They immunized monkeys with adenovirus-36 vectors engineered to express SIV (simian immunodeficiency virus) genes and then boosted them with a recombinant gp120 envelope glycoprotein (Env) from SIV. This regimen afforded greater protection than a strategy that instead used a viral vector–based boost. A parallel trial using a SHIV (simian/human immunodeficiency virus)–based vaccine and challenge model produced similar results. Whether this particular approach will be equally successful in humans remains to be tested. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6245" page="320" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aab3886">320</jats:related-article> </jats:p>

<jats:title>Biochemical basis of a 24-hour clock</jats:title> <jats:p> Circadian clocks keep organisms in synch with such daily cycles as illumination, activity, and food availability. The circadian clock in cyanobacteria has the necessary 24-hour period despite its three component proteins having biochemical activities that occur on a much faster time scale. Abe <jats:italic>et al.</jats:italic> focused on the cyanobacterial clock component KaiC, an adenosine triphosphatase (ATPase) that can autophosphorylate and autodephosphorylate. The slow ATPase activity of KaiC, which is linked to a peptide isomerisation, provided the slow kinetics that set the speed of the 24-hour clock. Chang <jats:italic>et al.</jats:italic> found that another clock component, KaiB, also has slow changes in its protein conformation that help to set the oscillation period of the clock and its signaling output. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue pp. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6245" page="312" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.1261040">312</jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6245" page="324" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.1260031">324</jats:related-article> </jats:p>

<jats:title>How germ cells become sperm or egg</jats:title> <jats:p> During vertebrate development, germ cells switch from a sexually indifferent to a committed state for either egg or sperm. Signals from somatic gonadal cells are generally thought to influence the sexual differentiation of germ cells. However, Nishimura <jats:italic>et al.</jats:italic> demonstrate that germ cell–intrinsic sex determination cues are at play in the teleost fish medaka. The forkhead box transcriptional factor foxl3 represses the initiation of spermatogenesis. In the absence of foxl3 function, females develop ovaries filled with functional sperm. Thus, the male gonad environment is not required for spermatogenesis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6245" page="328" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aaa2657">328</jats:related-article> </jats:p>

<jats:p>Translational medicine might have many different interpretations depending on where you stand, but one thing is certain: it is a phrase that is now front and center in biomedical research around the globe. Touching many different fields of research, the intention of translational medicine is that basic research is “translated” rapidly into clinical applications that help patients by improving diagnosis, treatment, and follow up. This supplement to Science presents an overview of just some of the translational research being undertaken at China Capital Medical University. It covers a range of research areas, namely neuroscience, internal medicine, ophthalmology and otolaryngology, surgery and rehabilitation medicine, traditional Chinese medicine, and preventative medicine and clinical diagnosis.</jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>

<jats:p>On this week's show: Synthetic therapists and a roundup of daily news stories.</jats:p>

<jats:p>On this week's show: Synthetic therapists and a roundup of daily news stories.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Translational medicine might have many different interpretations depending on where you stand, but one thing is certain: it is a phrase that is now front and center in biomedical research around the globe. Touching many different fields of research, the intention of translational medicine is that basic research is “translated” rapidly into clinical applications that help patients by improving diagnosis, treatment, and follow up. This supplement to Science presents an overview of just some of the translational research being undertaken at China Capital Medical University. It covers a range of research areas, namely neuroscience, internal medicine, ophthalmology and otolaryngology, surgery and rehabilitation medicine, traditional Chinese medicine, and preventative medicine and clinical diagnosis.</jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>

<jats:p>Translational medicine might have many different interpretations depending on where you stand, but one thing is certain: it is a phrase that is now front and center in biomedical research around the globe. Touching many different fields of research, the intention of translational medicine is that basic research is “translated” rapidly into clinical applications that help patients by improving diagnosis, treatment, and follow up. This supplement to Science presents an overview of just some of the translational research being undertaken at China Capital Medical University. It covers a range of research areas, namely neuroscience, internal medicine, ophthalmology and otolaryngology, surgery and rehabilitation medicine, traditional Chinese medicine, and preventative medicine and clinical diagnosis.</jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>