Catálogo de publicaciones - revistas

<jats:title>Gut microbes make T cells keep the peace</jats:title> <jats:p> Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, <jats:italic>Clostridium</jats:italic> species of bacteria induce a type of T cell that promotes tolerance between the host and its microbial contents. Ohnmacht <jats:italic>et al.</jats:italic> and Sefik <jats:italic>et al.</jats:italic> characterized a population of gut regulatory T cells in mice, which required gut microbiota to survive. Multiple bacterial species of the microbiota could induce transcription factor–expressing regulatory T cells that helped maintain immune homeostasis. Mice engineered to lack these transcription factors exhibited enhanced susceptibility to colonic inflammation and had elevated amounts of proinflammatory molecules associated with allergies (see the Perspective by Hegazy and Powrie). </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue pp. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6251" page="989" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aac4263">989</jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6251" page="993" related-article-type="in-this-issue" vol="349" xlink:href="10.1126/science.aaa9420">993</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> Defining the morphological characteristics—such as the size, shape, or structure—of different cell types has played a key role in assessing the progression and status of various diseases. Imaging flow cytometry combines the visual analysis capabilities of microscopy with flow cytometry to provide researchers with a powerful tool to study cell morphology and the potential effects of therapeutic interventions. In this webinar, we will explore ways to characterize cell morphology and how this information can be applied to better understand blood disorders, including how erythrocyte morphology is used in the analysis of sickle cell disease and to identify functional intermediates in erythropoiesis. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://webinar.sciencemag.org/webinar/archive/characterizing-cell-morphology-using-imaging-flow-cytometry">View the Webinar</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>

<jats:p>On this week's show: The origin of moralizing gods, replicating 100 psychology experiments, and a roundup of daily news stories.</jats:p>