Catálogo de publicaciones - revistas

<jats:title>Opening up Vps34 protein complexes</jats:title> <jats:p> During intracellular membrane trafficking, large protein complexes regulate and adapt the activity of signal transducer enzymes such as the class III phosphatidylinositol 3-kinase Vps34. These large enzyme complexes are present in all eukaryotic cells, having widespread importance in neurodegeneration, aging, and cancer; however, a structural understanding has been lacking. Rostislavleva <jats:italic>et al.</jats:italic> provide atomic-resolution insights into the structures of the Vps34-containing protein complexes required for autophagy, endocytic sorting, and cytokinesis. The V-shaped complexes can undergo opening motions, which allows them to adapt to and phosphorylate membranes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aac7365">10.1126/science.aac7365</jats:related-article> </jats:p>

<jats:title>Ancient lake system at Gale crater</jats:title> <jats:p> Since 2012, the Curiosity rover has been diligently studying rocky outcrops on Mars, looking for clues about past water, climate, and habitability. Grotzinger <jats:italic>et al.</jats:italic> describe the analysis of a huge section of sedimentary rocks near Gale crater, where Mount Sharp now stands (see the Perspective by Chan). The features within these sediments are reminiscent of delta, stream, and lake deposits on Earth. Although individual lakes were probably transient, it is likely that there was enough water to fill in low-lying depressions such as impact craters for up to 10,000 years. Wind-driven erosion removed many of these deposits, creating Mount Sharp. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aac7575">10.1126/science.aac7575</jats:related-article> , see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6257" page="167" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad0902">167</jats:related-article> </jats:p>

<jats:title>Solutions for nanoparticle solutions</jats:title> <jats:p> Nanoparticle interactions in solution affect their binding to biomolecules, their electronic properties, and their packing into larger crystals. However, the theories that describe larger colloidal particles fail for nanoparticles, because the interactions do not add together linearly. Nanoparticles also have complex shapes and are closer in size to the solvent molecules. Silvera Batista <jats:italic>et al.</jats:italic> review approaches that can treat the nonadditive nature of nanoparticle interactions, resulting in a more complete understanding of nanoparticles in solution. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.1242477">10.1126/science.1242477</jats:related-article> </jats:p>

<jats:p>The upcoming Canadian election later this month will provide a welcome opportunity to reboot the federal government's controversial approach to science policy and research. The current Conservative government has been undermining science for the past 9 years, damaging the institutions that make scientific advancement possible and trying to ensure that political and ideological priorities dominate scientific work.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Opponents of Prime Minister Stephen Harper try to make his record on research an issue in election.</jats:p>