Catálogo de publicaciones - revistas

<jats:title>Early signs of dementia</jats:title> <jats:p> There is currently no cure for Alzheimer's disease. One of the reasons could be that interventions start too late, when there is already irreversible damage to the brain. Developing a biomarker that would help to effectively start therapy at very early stages of the disease is thus of high interest. Kunz <jats:italic>et al.</jats:italic> studied neural correlates of spatial navigation in the entorhinal cortex in control study participants and individuals at risk of developing Alzheimer's. The at-risk group showed a different brain signal many decades before the onset of the disease, and they navigated differently in a virtual environment. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="430" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac8128">430</jats:related-article> </jats:p>

<jats:title>Methane cycling gets more diverse</jats:title> <jats:p> The production and consumption of methane by microorganisms play a major role in the global carbon cycle. Although these processes can occur in a range of environments, from animal guts to the deep ocean, these metabolisms are confined to the Archaea. Evans <jats:italic>et al.</jats:italic> used metagenomics to assemble two nearly complete archaeal genomes from deep groundwater methanogens (see the Perspective by Lloyd). The two reconstructed genomes are members of the recently described Bathyarchaeota and not the phylum to which all previously known methane-metabolizing archaea belonged. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="434" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac7745">434</jats:related-article> , see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="384" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad4066">384</jats:related-article> </jats:p>

<jats:title>Metered rehydration in pollen grains</jats:title> <jats:p> When a desiccated pollen grain lands on fertile territory, it rehydrates on the way to activating its growth and metabolic processes. Studying the small plant <jats:italic>Arabidopsis</jats:italic> , Hamilton <jats:italic>et al.</jats:italic> have identified a mechanosensory ion channel that responds to the distention of the plasma membrane as the pollen grain rehydrates. With this channel damaged or absent, the pollen grains germinated overenthusiastically but then showed a tendency to burst. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="438" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac6014">438</jats:related-article> </jats:p>

<jats:title>Mouse work may lead to male contraceptive</jats:title> <jats:p> Unintended pregnancies are a major health issue worldwide. Although oral contraceptives were developed decades ago for use in women, there are no male oral contraceptives. Miyata <jats:italic>et al.</jats:italic> show that genetic deletion or drug inhibition of sperm-specific calcineurin enzymes in mice cause male sterility (see the Perspective by Castaneda and Matzuk). Although calcineurin inhibitors resulted in male infertility within 2 weeks, fertility recovered 1 week after halting drug administration. Because the sperm-specific calcineuin complex is also found in humans, its inhibition may be a strategy for developing reversible male contraceptives. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="442" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad0836">442</jats:related-article> , see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="385" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad4425">385</jats:related-article> </jats:p>

<jats:title>Observing ultrafast myoglobin dynamics</jats:title> <jats:p> The oxygen-storage protein myoglobin was the first to have its three-dimensional structure determined and remains a workhorse for understanding how protein structure relates to function. Barends <jats:italic>et al.</jats:italic> used x-ray free-electron lasers with femtosecond short pulses to directly observe motions that occur within half a picosecond of CO dissociation (see the Perspective by Neutze). Combining the experiments with simulations shows that ultrafast motions of the heme couple to subpicosecond protein motions, which in turn couple to large-scale motions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="445" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac5492">445</jats:related-article> , see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="381" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad3371">381</jats:related-article> </jats:p>

<jats:title>Quality control one chloroplast at a time</jats:title> <jats:p> How do plant cells get rid of chloroplasts that are not working as they should? Woodson <jats:italic>et al.</jats:italic> describe a chloroplast quality-control pathway that allows for the selective elimination of individual chloroplasts. Damage by reactive oxygen species during photosynthesis is recognized by a ubiquitin ligase, which marks out damaged chloroplasts for degradation. The findings reveal how cells balance inherently stressful energy production with organelle turnover. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="450" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac7444">450</jats:related-article> </jats:p>

<jats:title>An Aluring new autoantibody target</jats:title> <jats:p> Autoimmunity is the immune system's ultimate act of betrayal. Cells designed to protect against invading microbes suddenly target the host instead. In the autoimmune disease systemic lupus erythematosus, antibodies target DNA and host proteins, including the RNA binding protein Ro60. Hung <jats:italic>et al.</jats:italic> discovered that Ro60 bound to endogenous Alu retroelements. They detected antibody-Ro60-Alu RNA immune complexes in the blood of individuals with lupus and an enrichment of Alu transcripts. Ro60 bound to Alu probably primes RNA-binding innate immune receptors within B cells, leading these cells to make antibodies that target Ro60-Alu RNA and drive disease-causing inflammation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6259" page="455" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac7442">455</jats:related-article> </jats:p>

<jats:p>On this week's show: What treating blindness in India can tell us about the brain and a roundup of daily news stories.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> This issue of <jats:italic>Science</jats:italic> includes the program of the 2016 AAAS Annual Meeting. The theme of the AAAS Annual Meeting in Washington, DC, 11 to 15 February 2016, is <jats:italic>Global Science Engagement</jats:italic> . </jats:p> <jats:p> A <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/cgi/reprint/350/6259/461.pdf">PDF</jats:ext-link> of the program as it appears in this issue is available here; for more information on the meeting (including registration forms and information on accommodations), please visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="www.aaas.org/meetings/">www.aaas.org/meetings/</jats:ext-link> . </jats:p>