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<jats:title>Brain keeps body size and shape in check</jats:title> <jats:p> Animal systems show amazing left-right symmetry—think of how our legs or arms, or the legs or wings of an insect, are matched in size and shape. Environmental insults and growth defects can challenge these developmental programs. In order to limit the resultant variation, juvenile organisms buffer variability through homeostatic mechanisms, so that the correct final size is attained. Vallejo <jats:italic>et al.</jats:italic> report that the <jats:italic>Drosophila</jats:italic> brain mediates such homeostatic control via an insulin-like peptide Dilp8 binding to the relaxin hormone receptor Lgr3. Lgr3 neurons distribute this information to other neuronal populations to adjust the hormones ecdysone, insulin, and juvenile hormone in a manner that stabilizes body and organ size. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aac6767">10.1126/science.aac6767</jats:related-article> </jats:p>

<jats:p> Long before geophysicist Michael Mann's hockeystick graph became the icon for anthropogenic global warming, the U.S. President's Science Advisory Committee [now known as the President's Council of Advisors on Science and Technology (PCAST)] cautioned President Lyndon B. Johnson that the continued release of CO <jats:sub>2</jats:sub> to the atmosphere from burning fossil fuels would “almost certainly cause significant changes” and “could be deleterious from the point of view of human beings.” The committee's report concluded that there could be “marked changes in climate, not controllable through local or even national efforts.” In recognition of the 50th anniversary of that first official warning from scientists to policy-makers, the American Association for the Advancement of Science (AAAS), the Carnegie Institution for Science, the American Meteorological Society, and the Linden Trust for Conservation sponsored a 1-day climate symposium on 29 October. </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>New study shows Mount St. Helens may share magma with other volcanoes nearby.</jats:p>

<jats:p>Unsung reactor fuel is more abundant than uranium and, proponents say, safer.</jats:p>

<jats:p>Accelerating retreat of a Greenland glacier could raise sea level for decades to come.</jats:p>

<jats:p>Nervous systems were well developed by the Cambrian explosion, having evolved in earlier organisms.</jats:p>

<jats:p>DNA registry could lead to new treatments.</jats:p>

<jats:p>Gene editing used to create “off-the-shelf” T cells.</jats:p>