Catálogo de publicaciones - revistas

<jats:title>Notch role in multipotency or cell fate</jats:title> <jats:p> Multipotent <jats:italic>Drosophila</jats:italic> intestinal stem cells (ISCs) generate either nutrient-absorbing enterocytes (ECs) or secretory enteroendocrine cells (EECs). Guo and Ohlstein investigated the role of Notch signaling in this process. They tracked ISC asymmetric divisions and found that EEC daughter cells, which have a low level of Notch, signal back to the ISC in order to keep it multipotent. However, during EC production, ISCs activate strong Notch signaling in daughters. Thus, Notch signaling functions in two directions to achieve stem cell multipotency. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aab0988">10.1126/science.aab0988</jats:related-article> </jats:p>

<jats:title>Help for neurodevelopmental disorders</jats:title> <jats:p>When the brain does not develop normally, the disabilities that ensue can affect a person for life. Sahin and Sur review how emerging knowledge of the molecular biology behind a suite of neurodevelopmental disorders is shedding light on the group as a whole. The new knowledge offers tantalizing leads toward more effective therapies.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aab3897">10.1126/science.aab3897</jats:related-article> </jats:p>

<jats:p>In 1863, U.S. President Abraham Lincoln delivered his now famous Gettysburg Address on the open field of that bloody Civil War battle. Not many speeches by political leaders get remembered beyond the moment. Even fewer ever get cut into stone. In this case, of course, both are true. We know the words. We recite passages from it. And, in its entirety, the speech graces a wall of the Lincoln Memorial in Washington, DC.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>A European space probe is set to pave the way for measurements of gravitational waves.</jats:p>

<jats:p>New voltage-sensor achieves submillisecond precision.</jats:p>

<jats:p>Small Business Innovation Research program makes almost no grants to African-Americans.</jats:p>