Catálogo de publicaciones - revistas

<jats:title>A change of heart (mitochondria)</jats:title> <jats:p> Mitochondria provide an essential source of energy to drive cellular processes and are particularly important in heart muscle cells (see the Perspective by Gottlieb and Bernstein). After birth, the availability of oxygen and nutrients to organs and tissues changes. This invokes changes in metabolism. Gong <jats:italic>et al.</jats:italic> studied the developmental transitions in mouse heart mitochondria soon after birth. Mitochondria were replaced wholesale via mitophagy in cardiomyocytes over the first 3 weeks after birth. Preventing this turnover by interfering with parkin-mediated mitophagy specifically in cardiomyocytes prevented the normal metabolic transition and caused heart failure. Thus, the heart has coopted a quality-control pathway to facilitate a major developmental transition after birth. Wai <jats:italic>et al.</jats:italic> examined the role of mitochondrial fission and fusion in mouse cardiomyocytes. Disruption of these processes led to “middle-aged” death from a form of dilated cardiomyopathy. Mice destined to develop cardiomyopathy were protected by feeding with a high-fat diet, which altered cardiac metabolism. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad2459">10.1126/science.aad2459</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad0116">10.1126/science.aad0116</jats:related-article> ; see also p. 1162 </jats:p>

<jats:title>A change of heart (mitochondria)</jats:title> <jats:p> Mitochondria provide an essential source of energy to drive cellular processes and are particularly important in heart muscle cells (see the Perspective by Gottlieb and Bernstein). After birth, the availability of oxygen and nutrients to organs and tissues changes. This invokes changes in metabolism. Gong <jats:italic>et al.</jats:italic> studied the developmental transitions in mouse heart mitochondria soon after birth. Mitochondria were replaced wholesale via mitophagy in cardiomyocytes over the first 3 weeks after birth. Preventing this turnover by interfering with parkin-mediated mitophagy specifically in cardiomyocytes prevented the normal metabolic transition and caused heart failure. Thus, the heart has coopted a quality-control pathway to facilitate a major developmental transition after birth. Wai <jats:italic>et al.</jats:italic> examined the role of mitochondrial fission and fusion in mouse cardiomyocytes. Disruption of these processes led to “middle-aged” death from a form of dilated cardiomyopathy. Mice destined to develop cardiomyopathy were protected by feeding with a high-fat diet, which altered cardiac metabolism. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad2459">10.1126/science.aad2459</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad0116">10.1126/science.aad0116</jats:related-article> ; see also p. 1162 </jats:p>

<jats:p>Japan is the frontrunner of aging societies in terms of longevity and the proportion of the elderly in the population. In 2030, one-third of the population will be older than age 65, and 20% will be older than 75 years. Moreover, 75-year-old seniors in Japan are as physically healthy as those a decade younger, according to a recent government survey. If Japan is to deal effectively with the highly aged society of the future, and benefit from this growing sector of its society, it must come up with a new socially inclusive system for people living into their nineties or more.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Researchers analyze sludge for heavy metals and assess potential for recovery.</jats:p>

<jats:p>Pharmaceutical firms and biotech companies embrace DNA-encoded chemical libraries.</jats:p>

<jats:p>Budget is protected for 5 years, but lags because of past inflation.</jats:p>

<jats:p>Akatsuki spacecraft aims to plumb planet's weird atmosphere.</jats:p>