Catálogo de publicaciones - revistas

<jats:title>Putting both heart and brain at risk</jats:title> <jats:p> For reasons that are unclear, newborns with congenital heart disease (CHD) have a high risk of neurodevelopmental disabilities. Homsy <jats:italic>et al.</jats:italic> performed exome sequence analysis of 1200 CHD patients and their parents to identify spontaneously arising (de novo) mutations. Patients with both CHD and neurodevelopmental disorders had a much higher burden of damaging de novo mutations, particularly in genes with likely roles in both heart and brain development. Thus, clinical genotyping of patients with CHD may help to identify those at greatest risk of neurodevelopmental disabilities, allowing surveillance and early intervention. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. 1262 </jats:p>

<jats:p> To isolate and study organelles from cells, scientists use methods that range from primitive to modern. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/site/products/lst_20151204.xhtml">Read the Feature (Full-Text HTML)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/site/products/lst_20151204.pdf">Read the Feature (PDF)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/site/products/lst_20151204_np.pdf">Read New Products (PDF)</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>

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<jats:p> It has been two decades since researchers at Stanford University showed that the progression of disease can be tracked noninvasively in living animals using bioluminescence imaging. Since then, researchers have developed and utilized a variety of molecular imaging techniques employing bioluminescence, fluorescence, chemiluminescence, and Cerenkov luminescence, combined with sophisticated imaging technologies, to increase our understanding of complex diseases and develop new therapeutic solutions. More recently, optical imaging has been combined with clinical imaging technologies, such as microcomputed tomography (microCT), magnetic resonance imaging (MRI), and positron emission tomography (PET) to produce multimodal imaging techniques that allow molecular, functional, and anatomical data to be seamlessly merged. This technology provides a more precise and rigorous method for exploring disease models in greater depth. In this webinar, our speakers will discuss the significant impact that imaging technologies have had on biomedicine and translational research, and how bioimaging might play a role in new and emerging scientific areas. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://webinar.sciencemag.org/webinar/archive/vivo-imaging-today-and-tomorrow">View the Webinar</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>