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<jats:p>Our editors scan the horizon for next year's hottest topics in science.</jats:p>

<jats:p> <jats:italic>Science</jats:italic> 's Breakdown of the Year was the Islamic State's efforts to erase the past by destroying antiquities and murdering scholars. Other setbacks for science included revelations of sexist attitudes and sexual harassment, and a court-ordered halt to construction of a giant telescope. </jats:p>

<jats:p> Rising temperatures and ocean acidifi cation drive changes in phytoplankton communities <jats:named-content content-type="related-content"> [Also see Reports by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6267" page="1530" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aaa9942"> McMahon <jats:italic>et al.</jats:italic> </jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6267" page="1533" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aaa8026"> Rivero-Calle <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p> Borophene—stable, single-atom-thick layers of boron—displays remarkable properties <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6267" page="1513" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad1080"> Mannix <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p> Contacts between superconductors are explored via their ultracold atomic gas analogs <jats:named-content content-type="related-content"> [Also see Reports by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6267" page="1498" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac9584"> Husmann <jats:italic>et al.</jats:italic> </jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6267" page="1505" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aac9725"> Valtolina <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p>Management of emerging risks in life science and technology requires new leadership and a sober assessment of the legacy of Asilomar</jats:p>

<jats:p>U.S. wolf-hunting policies do not align with ecological theory or data</jats:p>

<jats:p> A trisulfide intermediate is key to microbial sulfur reduction <jats:named-content content-type="related-content"> [Also see Report by <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6267" page="1541" related-article-type="in-this-issue" vol="350" xlink:href="10.1126/science.aad3558"> Santos <jats:italic>et al.</jats:italic> </jats:related-article> ] </jats:named-content> </jats:p>

<jats:p>Does learning commit neurons that are predisposed to recruitment to a memory network?</jats:p>

<jats:p>Cells are engineered for on-demand control of psoriasis</jats:p>