Catálogo de publicaciones - revistas

<jats:title>Microbial villages shape viral infections</jats:title> <jats:p>Viruses infecting the intestinal tract, such as noroviruses and rotaviruses, are major human pathogens. Despite facing an extreme environment within their hosts, which includes pH gradients, digestive enzymes, and the billions of microbes that inhabit human guts, these viruses somehow manage to survive and often thrive. Pfeiffer and Virgin review the complex microbial encounters that occur between enteric viruses and gut microbiota. Trans-kingdom interactions (that is, between viruses, bacteria, archaea, helminthes, fungi, and phage) are particularly important in shaping the course of a viral infection and the ensuing host immune response.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad5872">10.1126/science.aad5872</jats:related-article> </jats:p>

<jats:title>Identifying the IRESs of humans and viruses</jats:title> <jats:p> Most proteins result from the translation of 5′ capped RNA transcripts. In viruses and a subset of human genes, RNA transcripts with internal ribosome entry sites (IRESs) are uncapped. Weingarten-Gabbay <jats:italic>et al.</jats:italic> systematically surveyed the presence of IRESs in human protein-coding transcripts, as well those of viruses (see the Perspective by Gebauer and Hentze). Large-scale mutagenesis profiling identified two classes of IRESs: those having a functional element localized to one small region of the IRES and those with important elements distributed across the entire region. An unbiased screen across human genes suggests that IRESs are more frequent than previously supposed in 3′ untranslated regions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad4939">10.1126/science.aad4939</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6270" page="228" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad8540">228</jats:related-article> </jats:p>

<jats:p>Long ago, U.S. business learned the benefits of constantly soliciting advice from workers on the shop floor by studying the startling success of the Japanese automobile industry. But the vast majority of U.S. school districts have remained hierarchical operations that ignore the wisdom available from their best classroom teachers. After decades of failed top-down solutions, now is the time to create a massive national movement that empowers and deeply respects our teachers. Scientists and science teachers can lead the way.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>