Catálogo de publicaciones - revistas

<jats:title>Rehomogenizing the Earth-Moon system</jats:title> <jats:p> A giant impact formed the Moon, and lunar rocks provide insight into that process. Young <jats:italic>et al.</jats:italic> found that rocks on Earth and the Moon have identical oxygen isotopes. This suggests that well-mixed material from the giant impact must have formed both the Moon and Earth's mantle. The finding also constrains the composition of the “late veneer”: material sprinkled onto Earth after the Moon-forming impact. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6272" page="493" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0525">493</jats:related-article> </jats:p>

<jats:title>Doubling down on polymerization</jats:title> <jats:p> In biology, structural polymers such as cytoskeletal fibers assemble from covalently polymerized monomers through weaker supramolecular interactions such as hydrogen bonds. Yu <jats:italic>et al.</jats:italic> report the synthesis of cylindrical fibers when three monomers react, two covalently and one in a supramolecular fashion. When the reaction proceeded stepwise, lower-molecular-weight flat tapes formed instead, which suggests that supramolecular interactions helped to catalyze the covalent polymerization. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6272" page="497" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad4091">497</jats:related-article> </jats:p>

<jats:title>Airway infections put to an acid test</jats:title> <jats:p> Most people with cystic fibrosis suffer from chronic respiratory infections. The mechanistic link between this symptom and the genetic cause of the disease (mutations that compromise the function of the cystic fibrosis transmembrane conductance regulator, CFTR) is not fully understood. Studying animal models, Shah <jats:italic>et al.</jats:italic> find that in the absence of functional CFTR, the surface liquid in the airways becomes acidic, which impairs host defenses against infection. This acidification occurs through the action of a proton pump called ATP12A. Molecules inhibiting ATP12A could potentially be developed into useful drugs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6272" page="503" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad5589">503</jats:related-article> </jats:p>

<jats:title>A special way to make T</jats:title> <jats:p> The genomes of all cell-based life consist of DNA. Blocking DNA synthesis is thus lethal, and if targeted selectively, its inhibition can provide cancer and antibiotic treatments. For example, the drug methotrexate interferes with the synthesis of thymidine, the base T in DNA. Mishanina <jats:italic>et al.</jats:italic> found that the enzyme that carries out the last step of thymidine synthesis in several human pathogens, which cause tuberculosis, anthrax, and typhus, uses a previously undescribed mechanism. Knowing the mechanism may allow the development of specific inhibitors for this enzyme. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6272" page="507" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0300">507</jats:related-article> </jats:p>

<jats:title>All T cells can remember</jats:title> <jats:p> One of the hallmarks of adaptive immunity is that T and B lymphocytes “remember” previous infections, protecting the host from subsequent infections. When T cells respond to a pathogen, they proliferate, and a fraction of their progeny goes on to form long-lived memory cells. It is not clear whether all of the T cell clones that respond to the initial infection have the potential to form memory T cells. Tubo <jats:italic>et al.</jats:italic> used a single-cell adoptive transfer model in mice to answer this question. Nearly all T cell clones produced memory cells, which suggests that breadth is probably an important component of immunological memory. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6272" page="511" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0483">511</jats:related-article> </jats:p>

<jats:title>Replacing the Y chromosome</jats:title> <jats:p> The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the sex-determining region Y (SRY) protein is necessary to initiate male sex determination. However, Yamauchi <jats:italic>et al.</jats:italic> show that the functions of the entire Y chromosome can be replaced with only two genes. In mice, two transgenes, <jats:italic>Sox9</jats:italic> and <jats:italic>Eif2s3x</jats:italic> , compensated for the absence of all Y chromosome genes to allow successful sperm formation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6272" page="514" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad1795">514</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>