Catálogo de publicaciones - revistas

<jats:title>Parasitic DNAs help and hinder evolution</jats:title> <jats:p> Transposable elements are parasitic DNAs that can duplicate themselves and jump around their host genomes. They can both disrupt gene function and drive genome evolution. Elbarbary <jats:italic>et al.</jats:italic> review the roles of two classes of transposable elements in gene regulation and disease: long interspersed elements (LINEs) and short interspersed elements (SINEs). Roughly a third of the human genome consists of LINEs and SINEs. They contribute to a broad range of important genome and gene regulatory features, while at the same time being responsible for number of human diseases. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aac7247">10.1126/science.aac7247</jats:related-article> </jats:p>

<jats:title>Genetic programming for self-renewal</jats:title> <jats:p> Instead of repopulating themselves from tissue-resident stem cell pools like most types of differentiated cells, tissue macrophages maintain themselves by self-renewing. The underlying genetic programs that allow for this, however, are unknown. Soucie <jats:italic>et al.</jats:italic> now report that in macrophages at homeostasis, a pair of transcription factors (MafB and c-Maf) bind to and repress the enhancers of genes regulating self-renewal. When macrophages need to replenish their stocks, for example in response to injury, they transiently decrease MafB and c-Maf expression so they can self-renew. A parallel pathway also operates to control the self-renewal of embryonic stem cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad5510">10.1126/science.aad5510</jats:related-article> </jats:p>

<jats:p>By now, the tragic saga of the lead-contaminated drinking water in Flint, Michigan, is well known. Unlike some disasters, this one was not inevitable, and there were many warning signs that could have halted it much sooner. In the developed world, citizens have come to trust that basic public services such as water, power, and sanitation will be provided, for a fee, safely and reliably. Therefore, Flint is not just a nightmare for its 100,000 residents, because it causes all citizens to question whether public officials, who are entrusted with providing essential services, have health and welfare in mind. With criminal investigation of the Flint crisis now under way, my focus is not on assigning blame but on how to prevent a tragedy like this from happening again.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>