Catálogo de publicaciones - revistas

<jats:title>A T cell cause for autism?</jats:title> <jats:p> The causes of autism spectrum disorder (ASD) are complex and not entirely clear. Alterations in the mother's immune system during pregnancy, especially during key early periods of fetal neurodevelopment, may play a role. Choi <jats:italic>et al.</jats:italic> provided infectious or inflammatory stimuli to pregnant mice, which resulted in of spring exhibiting behaviors reminiscent of ASD (see the Perspective by Estes and McAllister). A subset of T helper cells that make the cytokine interleukin-17a in the mothers caused cortical defects and associated ASD behaviors in offspring. Therapeutic targeting of interleukin-17a during gestation reduced ASD symptoms in offspring. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="933" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0314">933</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="919" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf2850">919</jats:related-article> </jats:p>

<jats:title>A partner protein for meiotic snip</jats:title> <jats:p> Eukaryotes generate germ cells through meiotic recombination. This process initiates through breaks in genomic DNA catalyzed by the SPO11 protein. Vrielynck <jats:italic>et al.</jats:italic> and Robert <jats:italic>et al.</jats:italic> discover that SPO11, like topoisomerase VI enzymes, interacts with a partner protein (see the Perspective by Bouuaert and Keeney). This partner is required for proper meiotic recombination and is found in a wide range of eukaryotes, suggesting that it is a universal feature of the essential recombination step. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="939" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad5196">939</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="943" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad5309">943</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="916" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf2509">916</jats:related-article> </jats:p>

<jats:title>A partner protein for meiotic snip</jats:title> <jats:p> Eukaryotes generate germ cells through meiotic recombination. This process initiates through breaks in genomic DNA catalyzed by the SPO11 protein. Vrielynck <jats:italic>et al.</jats:italic> and Robert <jats:italic>et al.</jats:italic> discover that SPO11, like topoisomerase VI enzymes, interacts with a partner protein (see the Perspective by Bouuaert and Keeney). This partner is required for proper meiotic recombination and is found in a wide range of eukaryotes, suggesting that it is a universal feature of the essential recombination step. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="939" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad5196">939</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="943" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad5309">943</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="916" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf2509">916</jats:related-article> </jats:p>

<jats:title>Silicon marries a chiral counterion</jats:title> <jats:p> Acid is among the oldest and most versatile of chemical catalysts, but its symmetrical protons can't guide reactions to favor a product over its mirror image. Chemists have resolved this shortcoming through the use of chiral conjugate bases. While the proton activates the substrate, the nearby counterion asymmetrically biases the space around it. Gatzenmeier <jats:italic>et al.</jats:italic> extend this approach to Lewis acid catalysis by silyl cations, which can activate a variety of substrates in complementary fashion to protons (see the Perspective by Dumoulin and Masson). By pairing these silyl groups with chiral carbon-based anions, they achieve highly enantioselective catalysis of Diels-Alder reactions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="949" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aae0010">949</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6276" page="918" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf2577">918</jats:related-article> </jats:p>