Catálogo de publicaciones - revistas

<jats:title>A more complete look at the HIV-1 envelope</jats:title> <jats:p> HIV-1 uses its envelope protein (Env), a large glycoprotein present on the viral surface, to enter target cells. Env forms trimers on the viral surface. Structural studies of solubilized Env trimers have provided important insights into viral entry and antibody binding, but soluble trimers lack several important insoluble regions of the native protein. Lee <jats:italic>et al.</jats:italic> used cryo–electron microscopy to solve the structure of a trimeric Env protein of HIV-1, missing only its cytoplasmic tail, in complex with broadly neutralizing antibodies. A more complete understanding of Env's structure may aid in vaccine design ef orts. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1043" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad2450">1043</jats:related-article> </jats:p>

<jats:title>Diversity reigns in antibody responses</jats:title> <jats:p> During the course of an immune response, B cells specific for an invading pathogen divide. The antibodies they produce increase in affinity via somatic mutation in specialized lymph node structures called germinal centers. Tas <jats:italic>et al.</jats:italic> used multiphoton microscopy and sequencing to determine how different B cell clones compete with one another within mouse germinal centers. Multiple B cell clones can seed individual germinal centers, and germinal centers lose diversity at disparate rates. Such heterogeneity suggests that manipulating minor clonal populations to gain an advantage during vaccination may one day be possible. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1048" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad3439">1048</jats:related-article> </jats:p>

<jats:title>Electrons that flow like a fluid</jats:title> <jats:p> Electrons inside a conductor are often described as flowing in response to an electric field. This flow rarely resembles anything like the familiar flow of water through a pipe, but three groups describe counterexamples (see the Perspective by Zaanen). Moll <jats:italic>et al.</jats:italic> found that the viscosity of the electron fluid in thin wires of PdCoO <jats:sub>2</jats:sub> had a major effect on the flow, much like what happens in regular fluids. Bandurin <jats:italic>et al.</jats:italic> found evidence in graphene of electron whirlpools similar to those formed by viscous fluid flowing through a small opening. Finally, Crossno <jats:italic>et al.</jats:italic> observed a huge increase of thermal transport in graphene, a signature of so-called Dirac fluids. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1061" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aac8385">1061</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1055" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0201">1055</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1058" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0343">1058</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1026" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf2487">1026</jats:related-article> </jats:p>

<jats:title>Electrons that flow like a fluid</jats:title> <jats:p> Electrons inside a conductor are often described as flowing in response to an electric field. This flow rarely resembles anything like the familiar flow of water through a pipe, but three groups describe counterexamples (see the Perspective by Zaanen). Moll <jats:italic>et al.</jats:italic> found that the viscosity of the electron fluid in thin wires of PdCoO <jats:sub>2</jats:sub> had a major effect on the flow, much like what happens in regular fluids. Bandurin <jats:italic>et al.</jats:italic> found evidence in graphene of electron whirlpools similar to those formed by viscous fluid flowing through a small opening. Finally, Crossno <jats:italic>et al.</jats:italic> observed a huge increase of thermal transport in graphene, a signature of so-called Dirac fluids. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1061" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aac8385">1061</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1055" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0201">1055</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1058" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0343">1058</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1026" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf2487">1026</jats:related-article> </jats:p>

<jats:title>Electrons that flow like a fluid</jats:title> <jats:p> Electrons inside a conductor are often described as flowing in response to an electric field. This flow rarely resembles anything like the familiar flow of water through a pipe, but three groups describe counterexamples (see the Perspective by Zaanen). Moll <jats:italic>et al.</jats:italic> found that the viscosity of the electron fluid in thin wires of PdCoO <jats:sub>2</jats:sub> had a major effect on the flow, much like what happens in regular fluids. Bandurin <jats:italic>et al.</jats:italic> found evidence in graphene of electron whirlpools similar to those formed by viscous fluid flowing through a small opening. Finally, Crossno <jats:italic>et al.</jats:italic> observed a huge increase of thermal transport in graphene, a signature of so-called Dirac fluids. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1061" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aac8385">1061</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1055" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0201">1055</jats:related-article> , <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1058" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aad0343">1058</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6277" page="1026" related-article-type="in-this-issue" vol="351" xlink:href="10.1126/science.aaf2487">1026</jats:related-article> </jats:p>