Catálogo de publicaciones - revistas

<jats:title>Single-cell expression profiles of melanoma</jats:title> <jats:p> Tumors harbor multiple cell types that are thought to play a role in the development of resistance to drug treatments. Tirosh <jats:italic>et al.</jats:italic> used single-cell sequencing to investigate the distribution of these differing genetic profiles within melanomas. Many cells harbored heterogeneous genetic programs that reflected two different states of genetic expression, one of which was linked to resistance development. Following drug treatment, the resistance-linked expression state was found at a much higher level. Furthermore, the environment of the melanoma cells affected their gene expression programs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6282" page="189" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad0501">189</jats:related-article> </jats:p>

<jats:title>All is well with particle-hole symmetry</jats:title> <jats:p> In an external magnetic field, the energy of an electron in a two-dimensional system takes discrete values, called Landau levels. At high enough fields, all electrons in a solid can fit in the lowest Landau level. If exactly half of that level is filled with electrons, standard theory predicts that a special fermion liquid phase will form that makes a distinction between the filled and empty states (particles and holes). A recent conjecture, in contrast, predicted a liquid consisting of massless Dirac particles that respects the symmetry between particles and holes. Geraedts <jats:italic>et al.</jats:italic> used sophisticated numerical methods to provide strong evidence for this conjecture. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6282" page="197" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad4302">197</jats:related-article> </jats:p>

<jats:title>Making magnetic atoms interact</jats:title> <jats:p> Two magnets interact with each other through a force that depends on the distance between them and on their mutual orientation. How do these long-range dipolar forces affect the behavior of a system of many magnets? Baier <jats:italic>et al.</jats:italic> used a gas of erbium atoms, which have a large magnetic moment, to answer this question. The gas—which they “housed” in an optical lattice—underwent a transition from a superfluid to an insulating state, revealing the presence of dipolar interactions through the orientation dependence of various properties. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6282" page="201" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aac9812">201</jats:related-article> </jats:p>

<jats:title>Assembling nanocrystal devices</jats:title> <jats:p> A wide range of materials can be grown as high-quality colloidal nanocrystals, with properties spanning from conductors to semiconductors and insulators. Although these materials have been included in electronic devices, they usually only form a single component within the device. Choi <jats:italic>et al.</jats:italic> took a variety of solution-processable colloidal nanocrystals to form all of the device components. Through the development of the right materials, interfaces, and processing steps, they constructed an all-colloid field effect transistor. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6282" page="205" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad0371">205</jats:related-article> </jats:p>

<jats:title>Making ribose in interstellar ices</jats:title> <jats:p> Astrobiologists have long speculated on the origin of prebiotic molecules such as amino acids and sugars. Meinert <jats:italic>et al.</jats:italic> demonstrated that numerous prebiotic molecules can be formed in an interstellar-analog sample containing a mixture of simple ices of water, methanol, and ammonia. They irradiated the sample with ultraviolet light under conditions similar to those expected during the formation of the solar system. This yielded a wide variety of sugars, including ribose—a major constituent of ribonucleic acid (RNA). </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6282" page="208" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad8137">208</jats:related-article> </jats:p>