Catálogo de publicaciones - revistas

<jats:title>The dragon sleeps tonight</jats:title> <jats:p> Most animal species sleep, from invertebrates to primates. However, neuroscientists have until now only actively recorded the sleeping brains of birds and mammals. Shein-Idelson <jats:italic>et al.</jats:italic> now describe the electrophysiological hallmarks of sleep in reptiles. Recordings from the brains of Australian dragons revealed the typical features of slow-wave sleep and rapid eye movement (REM) sleep. These findings indicate that the brainstem circuits responsible for slow-wave and REM sleep are not only very ancient but were already involved in sleep dynamics in reptiles. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6285" page="590" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf3621">590</jats:related-article> </jats:p>

<jats:title>Phase separation organizes signaling</jats:title> <jats:p> In T cell receptors, signaling molecules reorganize into tiny phase-separated droplets—like oil in water. Su <jats:italic>et al.</jats:italic> used an in vitro system with artificial membranes and 12 components of the T cell receptor signaling system to closely monitor the role of these molecular clusters (see the Perspective by Dustin and Muller). The clusters formed through phosphorylation-dependent association of the linker protein LAT (linker for activation of T cells) with other proteins. These clusters also managed to exclude an inactivating phosphatase and increased the specific activity of enzymes controlling actin polymerization. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6285" page="595" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad9964">595</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6285" page="516" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf8179">516</jats:related-article> </jats:p>

<jats:title>RNA splicing links genetics to disease</jats:title> <jats:p> Many genetic variants associated with disease have no apparent effect on any specific protein coding sequence. Li <jats:italic>et al.</jats:italic> systematically analyzed the effects of DNA variants on the main steps of gene regulation, from the chromatin state through protein function. One-third of expression quantitative train loci (QTLs) are mediated through transcriptional processes, not chromatin. Splice QTLs and expression QTLs are about comparable in their complex disease risk. Posttranscriptional mechanisms therefore play a large role in translating genotype to phenotype. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6285" page="600" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad9417">600</jats:related-article> </jats:p>

<jats:title>Identifying nonequilibrium dynamics</jats:title> <jats:p> Living systems clearly operate out of thermodynamic equilibrium at the molecular scale. How these activities are manifest at the cellular scale, however, has been unclear. Battle <jats:italic>et al.</jats:italic> use video microscopy together with statistical thermodynamics to unambiguously identify which random fluctuations at the cellular scale are out of equilibrium (see the Perspective by Rupprecht and Prost). Transitions between states obey a detailed balance in equilibrium, whereas imbalanced transitions point to nonequilibrium dynamics. For instance, nonequilibrium dynamics can be identified in the periodic beating of a flagellum and in the nonperiodic fluctuations of primary cilia. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6285" page="604" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aac8167">604</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6285" page="514" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf4611">514</jats:related-article> </jats:p>

<jats:title>Parasitic worms affect gut microbes</jats:title> <jats:p> Improved hygiene practices in high-income countries may come with an increased risk of developing inflammatory bowel disease (IBD) or other similar disorders. Ramanan <jats:italic>et al.</jats:italic> show that intestinal helminth infection, caused by parasitic worms, protects IBD-susceptible mice from developing the disease. The infection increases specific protective species and limits other inflammatory members of the microbiota. People from helminth-endemic regions harbored a similar protective microbiota, and their deworming led to an increase in inflammatory Bacteroidales species, similar to what the authors observed in the mice. Thus, a changing microbial environment may shape susceptibility to inflammatory disease. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6285" page="608" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf3229">608</jats:related-article> </jats:p>

<jats:p> Sometimes the latest equipment in a laboratory, say a next-generation sequencer, grabs lots of attention, but it's the workhorses—centrifuges, hoods, freezers, incubators, and more—that keep experiments and workflows moving. These general lab tools often determine how smoothly andcost effectively a lab runs. In large part, the results can be measured in one word—efficiency. In this case, efficiency means saving energy and time. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/custom-publishing/technology-features/adding-efficiency-general-lab-equipment">Read the Feature (Full-Text HTML)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/custom-publishing/documents/29%20April%20General%20Lab%20Equipment.pdf">Read the Feature (PDF)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/custom-publishing/douments/29%20April%20New%20Products.pdf">Read New Products (PDF)</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>